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Sökning: id:"swepub:oai:DiVA.org:oru-38248" > The Metabolically H...

  • Gauthier, Marie-SoleilInstitut de Recherches Cliniques de Montréal, Montréal QC, Canada; Montreal Diabetes Research Centre, Centre de Recherche du Centre Hospitalier de L'Université de Montréal (CRCHUM), Montréal QC, Canada (författare)

The Metabolically Healthy But Obese Phenotype Is Associated With Lower Plasma Levels of Persistent Organic Pollutants as Compared to the Metabolically Abnormal Obese Phenotype

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • The Endocrine Society,2014
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-38248
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-38248URI
  • https://doi.org/10.1210/jc.2013-3935DOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Genome Quebec (CAO project)J-A DeSeve Chair for Clinical ResearchCanadian Institutes of Health Research New Emerging Team in Obesity (University of Montreal and University of Ottawa, MONET project) T 0602145.02Norwegian Diabetes AssociationGrieg FoundationChina Scholarship Council 201206400003Research Council of Norway 228135
  • Context: Although obesity is strongly linked to insulin resistance and type 2 diabetes, a subset of obese individuals termed metabolically healthy but obese(MHO) appears relatively protected from the development of cardiometabolic complications. The origins of this metabolically healthy phenotype remain unclear. Recently, persistent organic pollutants (POPs) have emerged as potential endocrine disruptors.Objective: The aim of this study was to test the hypothesis that the MHO phenotype presents lower circulating levels of POPs as compared to the metabolically abnormal obese (MAO) phenotype.Design, Setting, and Patients: We conducted a cross-sectional study of 76 nondiabetic obese (body mass index >= 30 kg/m(2)) postmenopausal women.Main Outcome Measures: Plasma concentrations of 21 POPs as well as cardiometabolic risk factors were analyzed.Results: For similar age, body mass index, and fat mass index, MHO women (n = 40) showed higher insulin sensitivity levels and a more favorable cardiometabolic profile than MAO women (n = 36), as evidenced by a 2-fold increase in glucose disposal rates measured by the hyperinsulinemic-euglycemic clamp (P = .001). Among 18 detectable pollutants measured, MAO women had higher plasma concentrations of 12 POPs (fold increase, 1.4-2.9; P < .001-.036). Logistic regression analyses showed that the prevalence of the MAO phenotype was significantly associated with higher levels of total dioxin and non-dioxin-like polychlorinated biphenyls (odds ratio, 4.7; 95% confidence interval, 1.8-12.5; P = .002), as well as trans-nonachlor (odds ratio, 6.1; 95% CI, 2.2-16.4; P < .001).Conclusion: Our study demonstrates that the metabolically healthy and abnormal phenotypes have distinct plasma POP profiles.

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  • Rabasa-Lhoret, RemiInstitut de Recherches Cliniques de Montréal, Montréal QC, Canada; Montreal Diabetes Research Centre, Centre de Recherche du Centre Hospitalier de L'Université de Montréal (CRCHUM), Montréal QC, Canada; Nutrition Department, Université de Montréal, Montréal, Canada; Endocrinology Division, Montreal University Hospital, Montréal QC, Canada; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa ON, Canada (författare)
  • Prud'homme, DenisInstitut de Recherche de L'Hôpital Montfort, Ottawa ON, Canada (författare)
  • Karelis, Antony D.Department of Kinanthropology, Université du Québec À Montréal, Montréal QC, Canada (författare)
  • Geng, Dawei,1986-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)dgg (författare)
  • van Bavel, Bert,1963-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)bvl (författare)
  • Ruzzin, JeormeDepartment of Biology, University of Bergen, Bergen, Norway (författare)
  • Institut de Recherches Cliniques de Montréal, Montréal QC, Canada; Montreal Diabetes Research Centre, Centre de Recherche du Centre Hospitalier de L'Université de Montréal (CRCHUM), Montréal QC, CanadaInstitut de Recherches Cliniques de Montréal, Montréal QC, Canada; Montreal Diabetes Research Centre, Centre de Recherche du Centre Hospitalier de L'Université de Montréal (CRCHUM), Montréal QC, Canada; Nutrition Department, Université de Montréal, Montréal, Canada; Endocrinology Division, Montreal University Hospital, Montréal QC, Canada; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa ON, Canada (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society99:6, s. E1061-E10660021-972X1945-7197

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