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Folic acid suppleme...
Folic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to IVF pregnancy outcome
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- Murto, Tiina, 1975- (author)
- Uppsala universitet,Obstetrik & gynekologi
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- Kunovac Kallak, Theodora (author)
- Uppsala universitet,Obstetrik & gynekologi
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- Hoas, Annica (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Altmäe, Signe (author)
- Department of Paediatrics, School of Medicine, University of Granada, Granada, Spain; Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia
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- Salumets, Andres (author)
- Competence Centre on Reproductive Medicine and Biology, Tartu, Estonia; Institute of Biomedicine, University of Tartu, Tartu, Estonia
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- Nilsson, Torbjörn K (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap,Umeå University
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- Skoog Svanberg, Agneta (author)
- Uppsala universitet,Obstetrik & gynekologi
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- Wånggren, Kjell (author)
- Karolinska Institutet,Uppsala universitet,Obstetrik & gynekologi
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- Yngve, Agneta, 1953- (author)
- Karolinska Institutet,Örebro universitet,Restaurang- och hotellhögskolan,Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden,Örebro University, Karolinska Institutet
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- Stavreus-Evers, Anneli (author)
- Uppsala universitet,Obstetrik & gynekologi
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(creator_code:org_t)
- 2014-10-31
- 2014
- English.
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In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 94:1, s. 65-71
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Abstract
Subject headings
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- OBJECTIVE: To study folic acid intake, folate status and pregnancy outcome after infertility treatment in women with different infertility diagnoses in relation to methylenetetrahydrofolate reductase (MTHFR) 677C>T, 1298A>C and 1793G>A polymorphisms. Also the use of folic acid supplements, folate status and the frequency of different gene variations were studied in women undergoing infertility treatment and fertile women.DESIGN: Observational study.SETTING: University hospital.POPULATION: Women undergoing infertility treatment and healthy, fertile, non-pregnant women.METHODS: A questionnaire was used to assess general background data and use of dietary supplements. Blood samples were taken to determine plasma folate and homocysteine levels, and for genomic DNA extraction. A comparison of four studies was performed to assess pregnancy outcome in relation to MTHFR 677 TT vs. CC, and 1298 CC vs. AA polymorphisms.MAIN OUTCOME MEASURES: Folic acid supplement intake, and plasma folate, homocysteine and genomic assays.RESULTS: Women in the infertility group used significantly more folic acid supplements and had better folate status than fertile women, but pregnancy outcome after fertility treatment was not dependent on folic acid intake, folate status or MTHFR gene variations.CONCLUSION: High folic acid intakes and MTHFR gene variations seem not associated with helping women to achieve pregnancy during or after fertility treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Folate
- folic acid
- homocysteine
- infertility
- methylenetetrahydrofolate reductase
- pregnancy outcome
- Nutrition
- Näringslära
Publication and Content Type
- ref (subject category)
- art (subject category)
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Murto, Tiina, 19 ...
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Kunovac Kallak, ...
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Hoas, Annica
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Altmäe, Signe
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Salumets, Andres
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Nilsson, Torbjör ...
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Skoog Svanberg, ...
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Wånggren, Kjell
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Yngve, Agneta, 1 ...
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Stavreus-Evers, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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MEDICAL AND HEAL ...
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Örebro University
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Umeå University
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Uppsala University
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Karolinska Institutet