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  • Carvalho, Raquel N.Institute for Environment and Sustainability, European Commission-DG Joint Research Centre, Ispra, Italy (författare)

Mixtures of chemical pollutants at European legislation safety concentrations : how safe are they?

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • 2014-09-12
  • Oxford University Press (OUP),2014
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-38654
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-38654URI
  • https://doi.org/10.1093/toxsci/kfu118DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:RADAR 265721French Office Water and Aquatic EnvironmentFrench Ministry for Ecology and Sustainable Development P181 DRC50
  • The risk posed by complex chemical mixtures in the environment to wildlife and humans is increasingly debated, but has been rarely tested under environmentally relevant scenarios. To address this issue, two mixtures of 14 or 19 substances of concern (pesticides, pharmaceuticals, heavy metals, polyaromatic hydrocarbons, a surfactant, and a plasticizer), each present at its safety limit concentration imposed by the European legislation, were prepared and tested for their toxic effects. The effects of the mixtures were assessed in 35 bioassays, based on 11 organisms representing different trophic levels. A consortium of 16 laboratories was involved in performing the bioassays. The mixtures elicited quantifiable toxic effects on some of the test systems employed, including i) changes in marine microbial composition, ii) microalgae toxicity, iii) immobilization in the crustacean Daphnia magna, iv) fish embryo toxicity, v) impaired frog embryo development, and vi) increased expression on oxidative stress-linked reporter genes. Estrogenic activity close to regulatory safety limit concentrations was uncovered by receptor-binding assays. The results highlight the need of precautionary actions on the assessment of chemical mixtures even in cases where individual toxicants are present at seemingly harmless concentrations.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Arukwe, AugustineNorwegian University of Science & Technology, Trondheim, Norway (författare)
  • Ait-Aissa, SelimNational Institute for Industrial Environment and Risks, Verneuil en Halatte, France (författare)
  • Bado-Nilles, AnneNational Institute for Industrial Environment and Risks, Verneuil en Halatte, France; Reims University, Reims, France (författare)
  • Balzamo, StefaniaIstituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Rome, Italy (författare)
  • Baun, AndersDepartment of Environmental Engineering,Technical University of Denmark, Kgs Lyngby, Denmark (författare)
  • Belkin, ShimshonInstitute of Life Sciences, The Hebrew University, Jerusalem, Israel (författare)
  • Blaha, LudekFaculty of Science, RECETOX, Masaryk University, Brno, Czech Republic (författare)
  • Brion, FrancoisNational Institute for Industrial Environment and Risks, Verneuil en Halatte, France (författare)
  • Conti, DanielaIstituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Rome, Italy (författare)
  • Creusot, NicolasNational Institute for Industrial Environment and Risks, Verneuil en Halatte, France (författare)
  • Essig, YonaAnalytical and Environmental Sciences Division, King's College, London, UK (författare)
  • Ferrero, Valentina E. V.European Commission-DG Joint Research Centre, Institute for Environment and Sustainability, Ispra, Italy (författare)
  • Flander-Putrle, VesnaMarine Biology Station Piran, National Institute of Biology, Ljubljana, Slovenia (författare)
  • Furhacker, MariaUniversity of Natural Resources and Life Sciences, Vienna, Austria (författare)
  • Grillari-Voglauer, ReginaUniversity of Natural Resources and Life Sciences, Vienna, Austria (författare)
  • Hogstrand, ChristerDiabetes and Nutritional Sciences Division, King's College London, London, UK (författare)
  • Jonas, AdamFaculty of Science, RECETOX, Masaryk University, Brno, Czech Republic (författare)
  • Kharlyngdoh, Joubert B.,1982-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)jtbh (författare)
  • Loos, RobertEuropean Commission-DG Joint Research Centre, Institute for Environment and Sustainability, Ispra, Italy (författare)
  • Lundebye, Anne-KatrineNational Institute of Nutrition and Seafood Research, Bergen, Norway (författare)
  • Modig, Carina,1963-Örebro universitet,Institutionen för naturvetenskap och teknik,Life Science Center, Örebro University, Örebro, Sweden(Swepub:oru)cmg (författare)
  • Olsson, Per-Erik,1957-Örebro universitet,Institutionen för naturvetenskap och teknik,Life Science Center, Örebro University, Örebro, Sweden(Swepub:oru)pkon (författare)
  • Pillai, SmithaUniversity of Natural Resources and Life Sciences, Vienna, Austria (författare)
  • Polak, NatasaAnalytical and Environmental Sciences Division, King's College, London, UK (författare)
  • Potalivo, MonicaIstituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Rome, Italy (författare)
  • Sanchez, WilfriedNational Institute for Industrial Environment and Risks, Verneuil en Halatte, France (författare)
  • Schifferli, AndreaSwiss Centre for Applied Ecotoxicology, Eawag-EPFL, Dübendorf, Switzerland (författare)
  • Schirmer, KristinSwiss Centre for Applied Ecotoxicology, Eawag-EPFL, Dübendorf, Switzerland (författare)
  • Sforzini, SusannaDepartment of Environmental and Life Sciences, Universita del Piemonte Orientale Vercelli Novara Alessandria, Alessandria, Italy (författare)
  • Sturzenbaum, Stephen R.Analytical and Environmental Sciences Division, King's College, London, UK (författare)
  • Søfteland, LivNational Institute of Nutrition and Seafood Research, Bergen, Norway (författare)
  • Turk, ValentinaMarine Biology Station Piran, National Institute of Biology, Ljubljana, Slovenia (författare)
  • Viarengo, AldoDepartment of Environmental and Life Sciences, Università del Piemonte Orientale Vercelli Novara Alessandria, Alessandria, Italy (författare)
  • Werner, IngeSwiss Centre for Applied Ecotoxicology, Swiss Federal Institute of Aquatic Science and Technology ( Eawag-EPFL), Dübendorf, Switzerland (författare)
  • Yagur-Kroll, SharonInstitute of Life Sciences, The Hebrew University, Jerusalem, Israel (författare)
  • Zounkova, RadkaFaculty of Science, RECETOX, Masaryk University, Brno, Czech Republic (författare)
  • Lettieri, TeresaEuropean Commission-DG Joint Research Centre, Institute for Environment and Sustainability, Rome, Italy (författare)
  • Institute for Environment and Sustainability, European Commission-DG Joint Research Centre, Ispra, ItalyNorwegian University of Science & Technology, Trondheim, Norway (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Toxicological Sciences: Oxford University Press (OUP)141:1, s. 218-2331096-60801096-0929

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