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Biomarker Discovery...
Biomarker Discovery in Non-Small Cell Lung Cancer : Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation
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- Botling, Johan (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Botling
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- Edlund, Karolina (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Botling
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- Lohr, Miriam (author)
- Department of Statistics, TU Dortmund University, Dortmund, Germany
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- Hellwig, Birte (author)
- Department of Statistics, TU Dortmund University, Dortmund, Germany
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- Holmberg, Lars (author)
- Uppsala universitet,Endokrinkirurgi
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- Lambe, Mats G. (author)
- Karolinska Institutet
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- Berglund, Anders (author)
- Uppsala universitet,Endokrinkirurgi
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- Ekman, Simon (author)
- Uppsala universitet,Enheten för onkologi
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- Bergqvist, Michael (author)
- Uppsala universitet,Enheten för onkologi
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- Pontén, Fredrik (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Pontén
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- König, André (author)
- Department of Statistics, TU Dortmund University, Dortmund, Germany
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- Fernandes, Oswaldo (author)
- Cardiothoracic Surgery, Örebro University Hospital, Örebro, Sweden
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- Karlsson, Mats (author)
- Region Örebro län,Laboratory Medicine
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- Helenius, Gisela (author)
- Region Örebro län,Laboratory Medicine
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- Karlsson, Christina, 1968- (author)
- Örebro universitet, Institutionen för hälsovetenskap och medicin
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- Rahnenfuehrer, Jörg (author)
- Department of Statistics, TU Dortmund University, Dortmund, Germany
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- Hengstler, Jan G. (author)
- Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany
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- Micke, Patrick (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Botling
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 19:1, s. 194-204
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Purpose: Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict prognosis and therapy response. So far, the value of these multigene signatures in clinical practice is unclear, and the biologic importance of individual genes is difficult to assess, as the published signatures virtually do not overlap.Experimental Design: Here, we describe a novel single institute cohort, including 196 non-small lung cancers (NSCLC) with clinical information and long-term follow-up. Gene expression array data were used as a training set to screen for single genes with prognostic impact. The top 450 probe sets identified using a univariate Cox regression model (significance level P < 0.01) were tested in a meta-analysis including five publicly available independent lung cancer cohorts (n = 860).Results: The meta-analysis revealed 14 genes that were significantly associated with survival (P < 0.001) with a false discovery rate < 1%. The prognostic impact of one of these genes, the cell adhesion molecule 1 (CADM1), was confirmed by use of immunohistochemistry on tissue microarrays from 2 independent NSCLC cohorts, altogether including 617 NSCLC samples. Low CADM1 protein expression was significantly associated with shorter survival, with particular influence in the adenocarcinoma patient subgroup.Conclusions: Using a novel NSCLC cohort together with a meta-analysis validation approach, we have identified a set of single genes with independent prognostic impact. One of these genes, CADM1, was further established as an immunohistochemical marker with a potential application in clinical diagnostics. Clin Cancer Res; 19(1); 194-204. (c) 2012 AACR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Onkologi
- Oncology
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Botling, Johan
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Edlund, Karolina
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Lohr, Miriam
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Hellwig, Birte
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Holmberg, Lars
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Lambe, Mats G.
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Berglund, Anders
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Ekman, Simon
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Bergqvist, Micha ...
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Pontén, Fredrik
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König, André
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Fernandes, Oswal ...
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Karlsson, Mats
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Helenius, Gisela
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Karlsson, Christ ...
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Rahnenfuehrer, J ...
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Hengstler, Jan G ...
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Micke, Patrick
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Clinical Cancer ...
- By the university
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Örebro University
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Umeå University
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Uppsala University
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Karolinska Institutet