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Diastolic function ...
Diastolic function improves after resolution of takotsubo cardiomyopathy
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- Kumar, Sanjay (författare)
- Downstate Medical Center, State University of New York, Brooklyn NY, USA; Marshfield Clinic-Weston Center, Weston WI, USA
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- Waldenborg, Micael, 1981- (författare)
- Region Örebro län
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- Bhumireddy, Priya (författare)
- New York Methodist Hospital, Brooklyn NY, USA
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- Ramkissoon, Keshwar (författare)
- Downstate Medical Center, State University of New York, Brooklyn NY, USA
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- Loiske, Karin, 1978- (författare)
- Örebro University Hospital, Örebro, Sweden
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- Innasimuthu, Antony L. (författare)
- Downstate Medical Center, State University of New York, Brooklyn NY, USA
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- Grodman, Richard S. (författare)
- Downstate Medical Center, State University of New York, Brooklyn NY, USA
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- Heitner, John F. (författare)
- New York Methodist Hospital, Brooklyn NY, USA
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- Emilsson, Kent, 1963- (författare)
- Örebro University Hospital, Örebro, Sweden
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- Lazar, Jason M (författare)
- Downstate Medical Center, State University of New York, Brooklyn NY, USA
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(creator_code:org_t)
- 2014-09-10
- 2016
- Engelska.
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Ingår i: Clinical Physiology and Functional Imaging. - : Wiley-Blackwell. - 1475-0961 .- 1475-097X. ; 6:1, s. 17-24
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Takotsubo cardiomyopathy (TTC) is a condition of reversible left ventricular (LV) systolic dysfunction. However, the diastolic function (DF) manifestations of TTC have not been widely investigated. We performed a bicentric study with retrospective analysis of DF in patients with TTC, during onset and at follow-up.METHODS: Twenty-eight patients with TTC (64 ± 10 years, F 24) were included. All underwent echocardiograms acutely and at the recovery phase (average three months later). Diastolic and systolic function parameters were recorded, including E-wave velocity (E), A-wave velocity, E/A ratio, relaxation (e') and contractility (S') based on tissue Doppler velocities of the mitral annuli, ejection fraction (EF), left atrial (LA) size and DF stages.RESULTS: Recovery, including the mean difference with 95% confidence interval, was associated with tending improvement (i.e. uncorrected significance) in E [13 cm s(-1) (-24, -2·3), P = 0·02] and in E/A ratio [0·2 (-0·41, -0·02), P = 0·04], as well as significant improvement (after multiple comparison correction) in mean e' [2·0 cm s(-1) (-3·3, -1·2), P<0·001] and in A-wave duration [29 ms (-46·7, -12·7), P = 0·002]. LA area tended to decrease during recovery [-2 cm² (0·33, 2·4), P = 0·01]. Improvement in DF stages was significant between the phases (21% versus 58% defined as normal DF, P = 0·016). Improvement in LVEF correlated with improvement in mean e' (r = 0·52, P = 0·02).CONCLUSIONS: TTC is associated with an acute impairment of conventional DF variables, which improves during recovery. DF recovery seems to occur in parallel with systolic recovery in patients with TTC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- broken heart syndrome
- doppler
- echocardiography
- relaxation
- stress-induced cardiomyopathy
- Cardiology
- Kardiologi
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Kumar, Sanjay
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Waldenborg, Mica ...
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Bhumireddy, Priy ...
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Ramkissoon, Kesh ...
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Loiske, Karin, 1 ...
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Innasimuthu, Ant ...
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Grodman, Richard ...
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Heitner, John F.
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Emilsson, Kent, ...
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Lazar, Jason M
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