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Prognostic signific...
Prognostic significance of YWHAZ expression in localized prostate cancer
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- Rueenauver, K. (författare)
- Inst Pathol, Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany
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- Menon, R. (författare)
- Inst Pathol, Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany
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- Svensson, Maria A., 1980- (författare)
- Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Department of Laboratory Medicine, University Hospital of Örebro, Örebro, Sweden; Department of Urology, University Hospital of Örebro, Örebro, Sweden
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- Carlsson, Jessica, 1984- (författare)
- Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Department of Urology, University Hospital of Örebro, Örebro, Sweden
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- Vogel, W. (författare)
- Univ Hosp Bonn, Inst Pathol, Dept Prostate Canc Res, Bonn, Germany
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- Andrén, Ove, 1963- (författare)
- Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Department of Urology, University Hospital of Örebro, Örebro, Sweden
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- Nowak, M. (författare)
- Univ Hosp Bonn, Inst Pathol, Dept Prostate Canc Res, Bonn, Germany
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- Perner, S. (författare)
- Univ Hosp Bonn, Inst Pathol, Dept Prostate Canc Res, Bonn, Germany
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Transdiciplinary Prostate Cancer Partership (ToPCaP), Sweden (Andrén, Carlsson, Svensson, on behalf of or aff. to), Group author (författare)
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(creator_code:org_t)
- 2014-08-26
- 2014
- Engelska.
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Ingår i: Prostate Cancer and Prostatic Diseases. - : Nature Publishing Group. - 1365-7852 .- 1476-5608. ; 17:4, s. 310-314
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Prostate cancer (PCa) patients are often over-treated because of the lack of biomarkers needed to distinguish the lethal from the indolent form of PCa. YWHAZ was recently identified as a potential therapeutic target in castration-resistant PCa (CRPC). Therefore, this study focused on determining the prognostic significance of YWHAZ in localized PCa.METHODS: YWHAZ expression was assessed by immunohistochemistry on formalin-fixed paraffin-embedded tissue from 213 men who underwent radical prostatectomy. Kaplan-Meier analysis and Cox proportional-hazards models were, used to assess the prognostic value of YWHAZ intensity.RESULTS: High YWHAZ expression was strongly associated with high Gleason score at the time of diagnosis (P<0.001) and PSA relapse (P=0.001). Importantly, patients with high expression of YWHAZ had a higher risk of CRPC development (P=0.002) and reduced survival time (P=0.002).CONCLUSIONS: Our findings indicate that YWHAZ could serve as a promising prognostic biomarker in localized PCa to predict poor prognosis and to identify a subgroup of tumors, which might benefit from earlier adjuvant or YWHAZ-targeted therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Onkologi
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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