Prognostic significance of YWHAZ expression in localized prostate cancer

Rueenauver, K.Inst Pathol, Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany (author)

Funding Agencies:Wilhelm Sander Foundation 2011.077.1Rudolf-Becker-FoundationGerman Research Foundation (Deutsche Forschungsgemeinschaft (DFG), Emmy-Noether-Program) PE1179/2-1Medical Faculty of the University of Bonn (BONFOR)Note: ToPCaP is a multinational research institute w. research locations in seven western countries
BACKGROUND: Prostate cancer (PCa) patients are often over-treated because of the lack of biomarkers needed to distinguish the lethal from the indolent form of PCa. YWHAZ was recently identified as a potential therapeutic target in castration-resistant PCa (CRPC). Therefore, this study focused on determining the prognostic significance of YWHAZ in localized PCa.METHODS: YWHAZ expression was assessed by immunohistochemistry on formalin-fixed paraffin-embedded tissue from 213 men who underwent radical prostatectomy. Kaplan-Meier analysis and Cox proportional-hazards models were, used to assess the prognostic value of YWHAZ intensity.RESULTS: High YWHAZ expression was strongly associated with high Gleason score at the time of diagnosis (P<0.001) and PSA relapse (P=0.001). Importantly, patients with high expression of YWHAZ had a higher risk of CRPC development (P=0.002) and reduced survival time (P=0.002).CONCLUSIONS: Our findings indicate that YWHAZ could serve as a promising prognostic biomarker in localized PCa to predict poor prognosis and to identify a subgroup of tumors, which might benefit from earlier adjuvant or YWHAZ-targeted therapy.

Menon, R.Inst Pathol, Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany (author)
Svensson, Maria A.,1980-Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Department of Laboratory Medicine, University Hospital of Örebro, Örebro, Sweden; Department of Urology, University Hospital of Örebro, Örebro, Sweden(Swepub:oru)mass (author)
Carlsson, Jessica,1984-Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Department of Urology, University Hospital of Örebro, Örebro, Sweden(Swepub:oru)jccn (author)
Vogel, W.Univ Hosp Bonn, Inst Pathol, Dept Prostate Canc Res, Bonn, Germany (author)
Andrén, Ove,1963-Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Department of Urology, University Hospital of Örebro, Örebro, Sweden(Swepub:oru)oan (author)
Nowak, M.Univ Hosp Bonn, Inst Pathol, Dept Prostate Canc Res, Bonn, Germany (author)
Perner, S.Univ Hosp Bonn, Inst Pathol, Dept Prostate Canc Res, Bonn, Germany (author)
Transdiciplinary Prostate Cancer Partership (ToPCaP), Sweden (Andrén, Carlsson, Svensson, on behalf of or aff. to), Group author (author)
Region Örebro länInst Pathol, Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany (creator_code:org_t)

In:Prostate Cancer and Prostatic Diseases: Nature Publishing Group17:4, s. 310-3141365-78521476-5608

By the author/editor: Rueenauver, K.; Menon, R.; Svensson, Maria ...; Carlsson, Jessic ...; Vogel, W.; Andrén, Ove, 196 ...; show more...; Nowak, M.; Perner, S.; Transdiciplinary ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

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