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Growth hormone dose...
Growth hormone dose-dependent pubertal growth : a randomized trial in short children with low growth hormone secretion
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- Albertsson-Wikland, Kerstin, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Kriström, Berit (author)
- Umeå universitet,Pediatrik,berit.kristrom@umu.se,Pediatrics Unit, Department of Clinical Sciences, Umeå University, Sweden
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- Lundberg, Elena (author)
- Umeå universitet,Pediatrik,Pediatrics Unit, Department of Clinical Sciences, Umeå University, Sweden
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- Aronson, A. Stefan (author)
- Dept Pediat, Halmstad Cty Hosp, Halmstad, Sweden,Department of Pediatrics, Halmstad Hospital, Sweden
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- Gustafsson, Jan, 1948- (author)
- Uppsala universitet,Pediatrik,Barnendokrinologisk forskning/Gustafsson
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- Hagenäs, Lars (author)
- Karolinska Institutet
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- Ivarsson, Sten (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Department of Pediatrics, Lund University, Malmö, Sweden
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- Jonsson, Björn, 1939- (author)
- Uppsala universitet,Pediatrik,Barnendokrinologisk forskning/Gustafsson
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- Ritzen, Martin (author)
- Karolinska Institutet
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- Tuvemo, Torsten, 1940- (author)
- Uppsala universitet,Pediatrik,Barnendokrinologisk forskning/Gustafsson
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- Westgren, Ulf (author)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Pediatrics, Lund University, Malmö, Sweden
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- Westphal, Otto, 1935 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Åman, Jan, 1948- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,School of Health and Medical Sciences, Örebro University, Sweden
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(creator_code:org_t)
- 2014-08-28
- 2014
- English.
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In: Hormone Research in Paediatrics. - : S. Karger AG. - 1663-2818 .- 1663-2826. ; 82:3, s. 158-170
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Abstract
Subject headings
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- Background/Aims: Growth hormone (GH) treatment regimens do not account for the pubertal increase in endogenous GH secretion. This study assessed whether increasing the GH dose and/or frequency of administration improves pubertal height gain and adult height (AH) in children with low GH secretion during stimulation tests, i. e. idiopathic isolated GH deficiency.Methods: A multicenter, randomized, clinical trial (No. 88-177) followed 111 children (96 boys) at study start from onset of puberty to AH who had received GH(33) mu g/kg/day for >= 1 year. They were randomized to receive 67 mu g/kg/day (GH(67)) given as one (GH(67x1); n = 35) or two daily injections (GH(33x2); n = 36), or to remain on a single 33 mu g/kg/day dose (GH(33x1); n = 40). Growth was assessed as height SDS gain for prepubertal, pubertal and total periods, as well as AH SDS versus the population and the midparental height.Results: Pubertal height SDS gain was greater for patients receiving a high dose (GH(67), 0.73) than a low dose (GH(33x1), 0.41, p < 0.05). AH(SDS) was greater on GH(67) (GH(67x1), -0.84; GH(33x2), -0.83) than GH(33) (-1.25, p < 0.05), and height SDS gain was greater on GH(67) than GH(33) (2.04 and 1.56, respectively; p < 0.01). All groups reached their target height SDS.Conclusion: Pubertal height SDS gain and AH SDS were dose dependent, with greater growth being observed for the GH(67) than the GH(33) randomization group; however, there were no differences between the once-and twice-daily GH(67) regimens. (C) 2014 S. Karger AG, Basel.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Gain in height
- Prepubertal growth
- Growth hormone frequency
- Delayed infancy-childhood transition
- Puberty
- Pediatrik
- Pediatrics
- Gain in height
- Prepubertal growth
- Growth hormone frequency
- Delayed
- infancy-childhood transition
- Puberty
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Albertsson-Wikla ...
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Kriström, Berit
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Lundberg, Elena
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Aronson, A. Stef ...
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Gustafsson, Jan, ...
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Hagenäs, Lars
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Ivarsson, Sten
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Jonsson, Björn, ...
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Ritzen, Martin
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Tuvemo, Torsten, ...
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Westgren, Ulf
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Westphal, Otto, ...
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Åman, Jan, 1948-
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Hormone Research ...
- By the university
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Örebro University
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Umeå University
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Lund University
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Uppsala University
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University of Gothenburg
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Karolinska Institutet