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Identification of T...
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Schuck, Sebastian DDepartment of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
(author)
Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-05-18
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San Fransisco, USA :Public Library Science,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-40631
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-40631URI
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https://doi.org/10.1371/journal.pone.0005590DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: T-cell responses against dormancy-, resuscitation-, and reactivation-associated antigens of Mycobacterium tuberculosis are candidate biomarkers of latent infection in humans.Methodology/Principal findings: We established an assay based on two rounds of in vitro restimulation and intracellular cytokine analysis that detects T-cell responses to antigens expressed during latent M. tuberculosis infection. Comparison between active pulmonary tuberculosis (TB) patients and healthy latently M. tuberculosis-infected donors (LTBI) revealed significantly higher T-cell responses against 7 of 35 tested M. tuberculosis latency-associated antigens in LTBI. Notably, T cells specific for Rv3407 were exclusively detected in LTBI but not in TB patients. The T-cell IFNgamma response against Rv3407 in individual donors was the most influential factor in discrimination analysis that classified TB patients and LTBI with 83% accuracy using cross-validation. Rv3407 peptide pool stimulations revealed distinct candidate epitopes in four LTBI.Conclusions: Our findings further support the hypothesis that the latency-associated antigens can be exploited as biomarkers for LTBI.
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Mueller, HenrikDepartment of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
(author)
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Kunitz, FrankRespiratory Diseases Clinic Heckeshorn, Department of Pneumology, HELIOS Klinikum Emil von Behring, Berlin, Germany
(author)
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Neher, AlbertAsklepios Professional Clinic München-Gauting, Centre for Pneumology and Thorax Surgery, Munich, Germany
(author)
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Hoffmann, HaraldAsklepios Professional Clinic München-Gauting, Centre for Pneumology and Thorax Surgery, Munich, Germany
(author)
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Franken, Kees L C MDepartment of Immunohematology & Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
(author)
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Repsilber, Dirk,1971-Research Institute for the Biology of Farm Animals, Genetics and Biometry, Dummerstorf, Germany(Swepub:oru)drr
(author)
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Ottenhoff, Tom H MDepartment of Immunohematology & Blood Transfusion/Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
(author)
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Kaufmann, Stefan H EDepartment of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
(author)
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Jacobsen, MarcDepartment of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
(author)
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Department of Immunology, Max Planck Institute for Infection Biology, Berlin, GermanyRespiratory Diseases Clinic Heckeshorn, Department of Pneumology, HELIOS Klinikum Emil von Behring, Berlin, Germany
(creator_code:org_t)
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In:PLOS ONESan Fransisco, USA : Public Library Science4:51932-6203
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Schuck, Sebastia ...
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Mueller, Henrik
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Kunitz, Frank
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Neher, Albert
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Hoffmann, Harald
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Repsilber, Dirk, ...
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