SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:oru-40642"
 

Sökning: id:"swepub:oai:DiVA.org:oru-40642" > The metabolic respo...

  • Baxter, Charles JDepartment of Plant Sciences, University of Oxford, Oxford, United Kingdom (författare)

The metabolic response of heterotrophic Arabidopsis cells to oxidative stress

  • Artikel/kapitelEngelska2007

Förlag, utgivningsår, omfång ...

  • 2006-11-22
  • Rockville, USA :American Society of Plant Biologists,2007
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-40642
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-40642URI
  • https://doi.org/10.1104/pp.106.090431DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • To cope with oxidative stress, the metabolic network of plant cells must be reconfigured either to bypass damaged enzymes or to support adaptive responses. To characterize the dynamics of metabolic change during oxidative stress, heterotrophic Arabidopsis (Arabidopsis thaliana) cells were treated with menadione and changes in metabolite abundance and (13)C-labeling kinetics were quantified in a time series of samples taken over a 6 h period. Oxidative stress had a profound effect on the central metabolic pathways with extensive metabolic inhibition radiating from the tricarboxylic acid cycle and including large sectors of amino acid metabolism. Sequential accumulation of metabolites in specific pathways indicated a subsequent backing up of glycolysis and a diversion of carbon into the oxidative pentose phosphate pathway. Microarray analysis revealed a coordinated transcriptomic response that represents an emergency coping strategy allowing the cell to survive the metabolic hiatus. Rather than attempt to replace inhibited enzymes, transcripts encoding these enzymes are in fact down-regulated while an antioxidant defense response is mounted. In addition, a major switch from anabolic to catabolic metabolism is signaled. Metabolism is also reconfigured to bypass damaged steps (e.g. induction of an external NADH dehydrogenase of the mitochondrial respiratory chain). The overall metabolic response of Arabidopsis cells to oxidative stress is remarkably similar to the superoxide and hydrogen peroxide stimulons of bacteria and yeast (Saccharomyces cerevisiae), suggesting that the stress regulatory and signaling pathways of plants and microbes may share common elements.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Redestig, HenningMax-Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany (författare)
  • Schauer, NicolasMax-Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany (författare)
  • Repsilber, Dirk,1971-ax-Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany(Swepub:oru)drr (författare)
  • Patil, Kiran RCenter for Microbial Biotechnology, BioCentrum Technical University of Denmark, Kongens Lyngby, Denmark (författare)
  • Nielsen, JensMax-Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany (författare)
  • Selbig, JoachimMax-Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany (författare)
  • Liu, JunliGenetics Programme, Scottish Crop Research Institute, Dundee, United Kingdom (författare)
  • Fernie, Alisdair RMax-Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany (författare)
  • Sweetlove, Lee JDepartment of Plant Sciences, University of Oxford, Oxford, United Kingdom (författare)
  • Department of Plant Sciences, University of Oxford, Oxford, United KingdomMax-Planck Institute for Molecular Plant Physiology, Potsdam-Golm, Germany (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Plant PhysiologyRockville, USA : American Society of Plant Biologists143:1, s. 312-250032-08891532-2548

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy