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In vivo and in vitr...
In vivo and in vitro toxicity of fractionated fish lipids, with particular regard to their content of chlorinated organic compounds
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- Håkansson, H. (author)
- Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Sundin, P. (author)
- Chemical Ecology and Ecotoxicology, Department of Ecology, Lund University, Lund, Sweden
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- Andersson, T. (author)
- Department of Zoophysiology, University of Göteborg, Göteborg, Sweden
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- Brunström, B. (author)
- Department of Zoophysiology, Uppsala University, Uppsala, Sweden
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- Dencker, L. (author)
- Department of Toxicology, Uppsala University, Uppsala, Sweden
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- Engwall, Magnus, 1965- (author)
- Department of Zoophysiology, Uppsala University, Uppsala, Sweden
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- Ewald, G. (author)
- Chemical Ecology and Ecotoxicology, Department of Ecology, Lund University, Lund, Sweden
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- Gilek, M. (author)
- Department of Zoology, Stockholm University, Stockholm, Sweden
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- Holm, G. (author)
- Department of Zoology, Stockholm University, Stockholm, Sweden; Swedish Environmental Research Institute, Stockholm, Sweden
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- Honkasalo, S. (author)
- Institute of Environmental Medicine, Karolinska Institutet, S-10401 Stockholm, Sweden
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- Idestam-Almquist, J. (author)
- Department of Botany, Stockholm University, Stockholm, Sweden
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- Jonsson, P. (author)
- Swedish Environmental Protection Agency, Solna, Sweden
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- Kautsky, N. (author)
- Department of Systems Ecology, Stockholm University, Stockholm, Sweden
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- Lundberg, G. (author)
- Swedish Environmental Research Institute, Stockholm, Sweden
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- Lund-Kvernheim, A. (author)
- Center for Industrial Research, Oslo, Norway
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- Martinsen, K. (author)
- Center for Industrial Research, Oslo, Norway
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- Norrgren, L. (author)
- Swedish Environmental Research Institute, Stockholm, Sweden; Department of Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden
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- Personen, M. (author)
- Department of Zoophysiology, University of Göteborg, Göteborg, Sweden
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- Rundgren, M. (author)
- Department of Toxicology, Karolinska Institutet, Stockholm, Sweden
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- Stålberg, M. (author)
- Institute of Environmental Medicine, Karolinska Institutet, S-10401 Stockholm, Sweden
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- Tarkpea, M. (author)
- Swedish Environmental Protection Agency, Aquatic Toxicology Section, Nyköping, Sweden
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- Wesén, C. (author)
- Department of Technical Analytical Chemistry, Chemical Center, Lund University, Lund, Sweden
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(creator_code:org_t)
- Wiley, 1991
- 1991
- English.
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In: Pharmacology and Toxicology. - : Wiley. - 0901-9928 .- 1600-0773. ; 69:6, s. 459-471
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Six different lipid matrices (the intact lipid (IL), four lipid fractions with different polarity, and the free fatty acids (FFAs) obtained by hydrolysis of the triacylglycerol (TAG) containing fraction) were obtained from salmon (Salmo salar) and eel (Anguilla anguilla), each collected at a contaminated and a comparatively uncontaminated catch site along the coast of Scandinavia. The lipid matrices were studied in toxicological test systems representing various biological functions of different organ systems from several species and trophic levels. The results were evaluated with particular respect to the concentrations of extractable organically bound chlorine (EOCl) in the matrices tested. In some test systems, the specimens with a higher EOCl concentration appeared to be more toxic. For example, the TAG containing fraction (F2) from Idefjord eel, having a higher EOCl content than F2 from Oslofjord eel, reduced the number and hatchability of eggs laid by zebrafish. Both IL and F2 of Idefjord eel increased mortality and reduced the oxygen/nitrogen-ratio in blue mussels. Non-polar compounds (F1) from Bothnian Sea salmon induced 7-ethoxyresurofin O-deethylase (EROD) activity in rainbow trout hepatocytes, whereas F1 from Senja salmon did not. F1 from Bothnian Sea salmon also reduced the number of T-cells in foetal mouse thymus anlagen in vitro compared with the cell number in anlagen exposed to F1 from Senja salmon. A positive correlation between EOCl concentration and test response was found for EROD activity in rainbow trout hepatocytes and for ATP-leakage in Erlich ascites tumour cells when testing the phospolipid containing fraction (F4). However, in most test systems the fish oils, irrespective of EOCl content, were of low toxicity, and the observed effects need to be verified in future studies.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- gas-chromatographic analysis
- brominated fatty-acids
- polychlorinated-biphenyls
- samples
- sediment
- embryos
- Enviromental Science
- Miljövetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Håkansson, H.
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Sundin, P.
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Andersson, T.
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Brunström, B.
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Dencker, L.
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Engwall, Magnus, ...
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show more...
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Ewald, G.
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Gilek, M.
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Holm, G.
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Honkasalo, S.
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Idestam-Almquist ...
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Jonsson, P.
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Kautsky, N.
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Lundberg, G.
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Lund-Kvernheim, ...
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Martinsen, K.
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Norrgren, L.
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Personen, M.
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Rundgren, M.
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Stålberg, M.
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Tarkpea, M.
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Wesén, C.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
- Articles in the publication
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Pharmacology and ...
- By the university
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Örebro University