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Differentiation of ...
Differentiation of human dermal fibroblasts towards endothelial cells
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- Junker, Johan (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Lönnqvist, Susanna (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Rakar, Jonathan (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Karlsson, Lisa K. (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Grenegård, Magnus, 1963- (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet
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- Kratz, Gunnar (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Hand- och plastikkirurgiska kliniken US
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(creator_code:org_t)
- Oxon, United Kingdom : Elsevier, 2013
- 2013
- English.
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In: Differentiation. - Oxon, United Kingdom : Elsevier. - 0301-4681 .- 1432-0436. ; 85:3, s. 67-77
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The ultimate goal of vascular tissue engineering is the production of functional grafts for clinical use. Difficulties acquiring autologous endothelial cells have motivated the search for alternative cell sources. Differentiation of dermal fibroblasts towards several mesenchymal lineages as well as endothelial cells has been proposed. The aim of the present study was to investigate the endothelial differentiation capacity of human dermal fibroblasts on a gene expression, protein expression and functional physiological level. Endothelial differentiation of fibroblasts was induced by culturing cells in 30% human serum, but not in fetal calf serum. Expression of proteins and genes relevant for endothelial function and differentiation was increased after induction. Furthermore, fibroblasts exposed to 30% human serum displayed increased uptake of low-density lipoprotein and formation of capillary-like networks. The results of this study may have an impact on cell sourcing for vascular tissue engineering, and the development of methods for vascularization of autologous tissue engineered constructs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Differentiation
- Endothelial cell
- Fibroblast
- Tissue engineering
- Human serum
- Biomedicin
- Biomedicine
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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