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No association betw...
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Fall, Katja,1971-Karolinska Institutet
(author)
No association between a polymorphic variant of the IRS-1 gene and prostate cancer risk
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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Hoboken, USA :John Wiley & Sons,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-41463
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-41463URI
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https://doi.org/10.1002/pros.20797DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:117549840URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objective: Insulin receptor substrate-1 (IRS-1) acts as a docking protein between the insulin-like growth factor-1 (IGF-1) receptor and intracellular signaling molecules in the IGF-1 signaling pathway. Accumulating data support a role of IGF-1 in prostate carcinogenesis. We assessed the influence of the most common IRS-1 gene polymorphism (Gly972Arg) on prostate cancer risk, alone and in combination with IGF-1 and other components in the IGF-1 signaling pathway.Materials and methods: In a nested case-control study within the Physicians' Health Study, the IRS-1 polymorphism was assayed from prospectively collected samples from 564 incident prostate cancer cases and 758 controls matched on age and smoking. We calculated relative risks (RR) and 95% confidence intervals (CI) using conditional logistic regression.Results: Among the controls, 0.8% were homozygous (AA) and 12% were heterozygous (GA) for the polymorphic allele. There was no association between carriage of the A allele and total prostate cancer risk (RR = 1.1 95% CI = 0.8-1.5), advanced disease (stage C or D or lethal prostate cancer, RR = 1.3 95% CI = 0.8-2.3), or plasma IGF-1 levels. We explored possible interactions with body mass index and components in the IGF-1 pathway including IGFBP3, PI3k, and PTEN but none of these factors influenced the relation between IRS-1 genotype and prostate cancer risk.Conclusions: Our data do not support an association between carriage of the variant IRS-1 gene and prostate cancer risk.
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Stark, J. R.Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham Women’s Hospital and Harvard Medical School, Boston, USA
(author)
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Mucci, L. A.Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
(author)
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Chan, J.Departments of Epidemiology & Biostatistics and Urology, University of California, San Francisco, USA
(author)
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Stampfer, M. J.Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
(author)
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Kurth, T.Department of Epidemiology, Harvard School of Public Health, Boston, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
(author)
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Febbo, P. G.Duke University School of Medicine, Durham, USA
(author)
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Kantoff, P.Division of Solid Tumor Oncology, Dana-Farber Cancer Institute, Boston, USA
(author)
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Ma, J.Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
(author)
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Karolinska InstitutetDepartment of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham Women’s Hospital and Harvard Medical School, Boston, USA
(creator_code:org_t)
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In:The ProstateHoboken, USA : John Wiley & Sons68:13, s. 1416-200270-41371097-0045
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Fall, Katja, 197 ...
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Stark, J. R.
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Mucci, L. A.
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Chan, J.
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Stampfer, M. J.
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Kurth, T.
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Febbo, P. G.
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Kantoff, P.
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Ma, J.
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The Prostate
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Örebro University
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Karolinska Institutet