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Binning metagenomic...
Binning metagenomic contigs by coverage and composition
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- Alneberg, Johannes (author)
- Science for Life Laboratory, School of Biotechnology, Division of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden
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- Bjarnason, Brynjar Smári, 1984- (author)
- Science for Life Laboratory, School of Biotechnology, Division of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden
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- de Bruijn, Ino (author)
- Bioinformatics Infrastructure for Life Sciences (BILS), Stockholm, Sweden
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- Schirmer, Melanie (author)
- School of Engineering, University of Glasgow, Glasgow, UK
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- Quick, Joshua (author)
- Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK; National Institute for Health Research (NIHR), Surgical Reconstruction and Microbiology Research Centre, University of Birmingham, Birmingham, UK
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- Ijaz, Umer Z. (author)
- School of Engineering, University of Glasgow, Glasgow, UK
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- Lahti, Leo (author)
- Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland; Laboratory of Microbiology, Wageningen University, Wageningen, the Netherlands
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- Loman, Nicholas J (author)
- Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK
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- Andersson, Anders F (author)
- Science for Life Laboratory, School of Biotechnoloy, Division of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden
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- Quince, Christopher (author)
- School of Engineering, University of Glasgow, Glasgow, UK
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(creator_code:org_t)
- 2014-09-14
- 2014
- English.
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In: Nature Methods. - : Springer Science and Business Media LLC. - 1548-7091 .- 1548-7105. ; 11:11, s. 1144-6
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Shotgun sequencing enables the reconstruction of genomes from complex microbial communities, but because assembly does not reconstruct entire genomes, it is necessary to bin genome fragments. Here we present CONCOCT, a new algorithm that combines sequence composition and coverage across multiple samples, to automatically cluster contigs into genomes. We demonstrate high recall and precision on artificial as well as real human gut metagenome data sets.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Alneberg, Johann ...
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Bjarnason, Brynj ...
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de Bruijn, Ino
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Schirmer, Melani ...
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Quick, Joshua
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Ijaz, Umer Z.
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show more...
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Lahti, Leo
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Loman, Nicholas ...
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Andersson, Ander ...
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Quince, Christop ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
- Articles in the publication
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Nature Methods
- By the university
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Örebro University