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Urinary melatonin l...
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Sigurdardottir, Lara G.Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Icelandic Cancer Society, Reykjavik, Iceland
(author)
Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men
- Article/chapterEnglish2015
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Elsevier,2015
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LIBRIS-ID:oai:DiVA.org:oru-42358
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-42358URI
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https://doi.org/10.1016/j.eururo.2014.07.008DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies:RANNIS (the Icelandic Research Fund)National Institutes of Health (NIH) National Center for Research Resources UL1-RR-025758 KL2-RR-025757Icelandic Cancer SocietyNIH National Cancer Institute R25-CA-098566 T32-CA-09001-35Prostate Cancer FoundationNIH National Institutes on Aging (NIA) N01-AG-12100Icelandic Heart AssociationIcelandic ParliamentNIH NIA P01-AG-009975
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Melatonin has anticarcinogenic properties in experimental models. We undertook a case-cohort study of 928 Icelandic men without prostate cancer (PCa) nested within the Age, Gene/Environment Susceptibility (AGES)-Reykjavik cohort to investigate the prospective association between first morning-void urinary 6-sulfatoxymelatonin (aMT6s) levels and the subsequent risk for PCa, under the hypothesis that men with lower aMT6s levels have an increased risk for advanced PCa. We used weighted Cox proportional hazards models to assess the association between first morning-void aMT6s levels and PCa risk, adjusting for potential confounders. A total of 111 men were diagnosed with incident PCa, including 24 with advanced disease. Men who reported sleep problems at baseline had lower morning aMT6s levels compared with those who reported no sleep problems. Men with morning aMT6s levels below the median had a fourfold statistically significant increased risk for advanced disease compared with men with levels above the median (hazard ratio: 4.04; 95% confidence interval, 1.26-12.98). These results require replication in larger prospective studies with longer follow-up.Patient summary: In this report, we evaluated the prospective association between urinary aMT6s levels and risk of PCa in an Icelandic population. We found that lower levels of aMT6s were associated with an increased risk for advanced PCa.
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Markt, Sarah C.Department of Epidemiology, Harvard School of Public Health, Boston MA, United States
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Rider, Jennifer R.Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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Haneuse, SebastienDepartment of Biostatistics, Harvard School of Public Health, Boston MA, United States
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Fall, Katja,1971-Örebro universitet,Institutionen för hälsovetenskap och medicin,Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Clinical Epidemiology Unit, Örebro University, Örebro University Hospital, Örebro, Sweden(Swepub:oru)kafl
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Schernhammer, Eva S.Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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Tamimi, Rulla M.Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston,MA, United States
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Flynn-Evans, ErinDivision of Sleep Medicine, Harvard Medical School, Boston MA, United States; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston MA, United States
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Batista, Julie L.Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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Launer, LenoreLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda MD, United States
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Harris, TamaraLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda MD, United States
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Aspelund, ThorCentre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland
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Stampfer, Meir J.Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
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Gudnason, VilmundurFaculty of Medicine, University of Iceland, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland
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Czeisler, Charles A.Division of Sleep Medicine, Harvard Medical School, Boston MA, United States; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston MA, United States
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Lockley, Steven W.Division of Sleep Medicine, Harvard Medical School, Boston MA, United States; Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston MA, United States
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Valdimarsdottir, Unnur A.Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard School of Public Health, Boston MA, United States
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Mucci, Lorelei A.Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard School of Public Health, Boston MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, United States
(author)
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Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Icelandic Cancer Society, Reykjavik, IcelandDepartment of Epidemiology, Harvard School of Public Health, Boston MA, United States
(creator_code:org_t)
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In:European Urology: Elsevier67:2, s. 191-1940302-28381873-7560
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