Sökning: WFRF:(Miniscalco Carmela 1963)
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Autism spectrum dis...
Autism spectrum disorder and low vitamin D at birth : a sibling control study
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- Fernell, Elisabeth, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,Gillberg Neuropsychiat Ctr, Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden; Res & Dev Ctr, Skaraborgs Hosp, Skövde, Sweden
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- Bejerot, Susanne, 1955- (författare)
- Karolinska Institutet,Dept Clin Neurosci, Karolinska Inst, Stockholm, Sweden
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- Westerlund, Joakim (författare)
- Stockholms universitet,Psykologiska institutionen
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- Miniscalco, Carmela, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,Gillberg Neuropsychiat Ctr, Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden
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- Simila, Henry (författare)
- Inst Brain, Univ Queensland, Brisbane Qld, Australia
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- Eyles, Darryl (författare)
- Inst Brain, Univ Queensland, Brisbane Qld, Australia; Queensland Ctr Mental Hlth Res, Univ Queensland, Brisbane Qld, Australia
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- Gillberg, Christopher, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre,Gillberg Neuropsychiat Ctr, Sahlgrenska Acad, Univ Gothenburg, Gothenburg, Sweden
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- Humble, Mats B., 1952- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2015
- 2015
- Engelska.
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Ingår i: Molecular Autism. - : Springer Science and Business Media LLC. - 2040-2392. ; 6
- Relaterad länk:
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https://doi.org/10.1...
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https://oru.diva-por... (primary) (Raw object)
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https://molecularaut...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background: Insufficient vitamin D activity has attracted increasing interest as a possible underlying risk factor in disorders of the central nervous system, including autism.Methods: In this study, 25-hydroxyvitamin D (25(OH) D) was analysed in 58 Sweden-born sibling pairs, in which one child had autism spectrum disorder (ASD) and the other did not. The study group consisted of two representative samples; 47 Gothenburg sibling pairs with mixed ethnicities and 11 Stockholm sibling pairs with Somali background. 25(OH) D levels were analysed in the stored dried blood spots taken in the neonatal period for metabolic screening.Results: The collapsed group of children with ASD had significantly lower vitamin D levels (M = 24.0 nM, SD = 19.6) as compared with their siblings (M = 31.9 nM, SD = 27.7), according to a paired samples t-test (P = 0.013). The difference was-most likely-not only accounted for by a difference in season of birth between ASD and non-ASD siblings since the mean 25(OH)D levels differed with similar effect size between the sibling pairs born during winter and summer, respectively. All children with African/Middle East background, both the children with ASD and their non-ASD siblings, had vitamin D deficiency.Conclusions: The findings suggest that low prenatal vitamin D may act as a risk factor for ASD, however, there is a need for replication with larger samples. Future research should study whether or not adequate supplementation of vitamin D to pregnant women might lower the risk for ASD in the offspring.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- Autism spectrum disorder
- Vitamin D
- 25-hydroxyvitamin D
- Neonatal
- Dried blood spots
- Neurology
- Neurologi
- 25-hydroxyvitamin D; Autism spectrum disorder; Dried blood spots; Neonatal; Vitamin D
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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