Search: (swepub) lar1:(oru) pers:(Tysk Curt) conttype:(refereed)
> (2015-2019) >
Enhanced levels of ...
Enhanced levels of chemokines and their receptors in the colon of microscopic colitis patients indicate mixed immune cell recruitment
-
- Gunaltay, Sezin, 1986- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
-
- Kumawat, Ashok Kumar, 1982- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Institute of Infection, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom
-
- Nyhlin, Nils, 1971- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län
-
show more...
-
- Bohr, Johan, 1957- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län
-
- Tysk, Curt, 1949- (author)
- Region Örebro län,Division of Gastroenterology, Department of Medicine, Örebro University, Örebro, Sweden
-
- Hultgren, Olof, 1970- (author)
- Region Örebro län
-
- Hultgren-Hörnquist, Elisabeth, 1965- (author)
- Örebro universitet,Institutionen för läkarutbildning
-
show less...
-
(creator_code:org_t)
- Hindawi Limited, 2015
- 2015
- English.
-
In: Mediators of Inflammation. - : Hindawi Limited. - 0962-9351 .- 1466-1861.
- Related links:
-
https://doi.org/10.1...
-
show more...
-
http://downloads.hin...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea. Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. We compared gene and protein expressions of different immune cell attracting chemokines and their receptors in colon biopsies from MC patients in active disease or histopathological remission (CC/LC-HR) with controls, using qRT-PCR and Luminex, respectively. CC and LC patients with active disease demonstrated a mixed chemokine profile with significantly enhanced gene and/or protein expressions of the chemokines CCL2, CCL3, CCL4, CCL5, CCL7, CCL22, CXCL8, CXCL9, CXCL10, CXCL11, and CX(3)CL1 and the receptors CCR2, CCR3, CCR4, CXCR1, CXCR2, and CX(3)CR1. Enhanced chemokine/chemokine receptor gene and protein levels in LC-HR patients were similar to LC patients, whereas CC-HR patients demonstrated almost normalized levels. These findings expand the current understanding of the involvement of various immune cells in MC immunopathology and endorse chemokines as potential diagnostic markers as well as therapeutic candidates. Moreover, this study further supports the hypothesis that CC and LC are two different entities due to differences in their immunoregulatory responses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Immunology
- Immunologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Gunaltay, Sezin, ...
-
Kumawat, Ashok K ...
-
Nyhlin, Nils, 19 ...
-
Bohr, Johan, 195 ...
-
Tysk, Curt, 1949 ...
-
Hultgren, Olof, ...
-
show more...
-
Hultgren-Hörnqui ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Mediators of Inf ...
- By the university
-
Örebro University