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Accuracy and reprod...
Accuracy and reproducibility of a quantitative magnetic resonance imaging method for concurrent measurements of tissue relaxation times and proton density
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- Krauss, Wolfgang, 1973- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Gunnarsson, Martin, 1973- (författare)
- Örebro universitet,Institutionen för läkarutbildning
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- Andersson, Torbjorn, 1948- (författare)
- Örebro universitet,Institutionen för läkarutbildning
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- Thunberg, Per, 1968- (författare)
- Department of Medical Physics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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(creator_code:org_t)
- Elsevier, 2015
- 2015
- Engelska.
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Ingår i: Magnetic Resonance Imaging. - : Elsevier. - 0730-725X .- 1873-5894. ; 33:5, s. 584-591
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: To evaluate the accuracy and reproducibility of a quantitative magnetic resonance (qMR) imaging method (QRAPMASTER) for simultaneous measurements of T1 and T2 relaxation times, and proton density (PD).Materials and Methods: Measurements of T1, T2, and PD with qMR were performed using phantoms with different relaxation times and concentrations of heavy water. Healthy volunteers were examined with different head coils. Regional measurements were performed in normal-appearing white and gray matter from the healthy control subjects, and in multiple sclerosis (MS) patients.Results: In phantom measurements, QRAPMASTER slightly underestimated T1, and T2 variations between repeated measurements were modest. PD was generally overestimated. The overall relative difference was 1.2 5.3% (T1), 6.6 1.9% (12), and 0.7 5.1% (PD). In healthy volunteers, there were no statistically significant differences of T1, T2 or PD using different head coils. Values of T1, T2, and PD obtained in healthy controls and MS patients were within reference ranges. However, significant differences were found in normal-appearing gray and white matter.Conclusion: QRAPMASTER can be considered a sufficiently accurate and reproducible method for use in clinical practice. Neuropathology in normal-appearing brain tissue may be revealed using this MR method, with putative implications for quantification of tissue damage in neurological diseases. (C) 2015 Elsevier Inc. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Quantitative MRI
- Synthetic MRI
- T1 mapping
- T2 mapping
- PD mapping
- Multiple sclerosis
- Radiology
- Radiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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