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Skeletal muscle tel...
Skeletal muscle telomere length is not impaired in healthy physically active old women and men
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- Ponsot, Elodie, 1973- (författare)
- Örebro universitet,Hälsoakademin,Muscle & Exercise Physiology Research Group , RISPA,Örebro University, Department of Health Sciences
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- Lexell, Jan (författare)
- Lund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Kadi, Fawzi, 1970- (författare)
- Örebro universitet,Hälsoakademin,Muscle & Exercise Physiology Research Group , RISPA,Örebro University, Department of Health Sciences
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(creator_code:org_t)
- Wiley, 2008
- 2008
- Engelska.
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Ingår i: Muscle and Nerve. - : Wiley. - 0148-639X .- 1097-4598. ; 37:4, s. 467-472
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We have previously shown that the number of satellite cells is lower in old than young men and women. The aim of this study was to further explore the effects of aging on the regenerative potential of skeletal muscle in 16 young and 26 old men and women with comparable physical activity level (young, 25 +/- 4 years; old, 75 +/- 4 years). Mean and minimum telomere lengths were determined using Southern blot analyses on biopsies obtained from the tibialis anterior muscle. There were no significant age or gender effects on mean and minimal telomeric lengths, suggesting that the replicative potential in the remaining satellite cells in the tibialis anterior muscle is not impaired with increasing age and the existence of in vivo regulatory mechanisms allowing the maintenance of telomere length. These results imply that moderate physical activity regularly performed by old subjects is not associated with accelerated telomere loss.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Tvärvetenskapliga studier inom samhällsvetenskap (hsv//swe)
- SOCIAL SCIENCES -- Other Social Sciences -- Social Sciences Interdisciplinary (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Adult
- Aged
- Aged; 80 and over
- Aging/*physiology
- Biopsy
- Female
- Humans
- Male
- Motor Activity/*physiology
- Muscle; Skeletal/cytology/*physiology
- Musculoskeletal Equilibrium/physiology
- Satellite Cells; Skeletal Muscle/cytology
- Telomere/*physiology
- Walking/physiology
- Physiology
- Fysiologi
- MEDICINE
- MEDICIN
- INTERDISCIPLINARY RESEARCH AREAS
- TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN
- Sports
- Idrott
- Sports Science
- Idrottsvetenskap
- telomere
- satellite cell
- regeneration
- aging
- exercise
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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