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Contrasting effects...
Contrasting effects of Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 on the composition of murine brain fatty acids and gut microbiota
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- Wall, Rebecca, 1979- (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland,Nutrition-Gut-Brain Interactions Research Centre
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- Marques, Tatiana M. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland: Department of Microbiology, University College Cork, Cork, Ireland
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- O'Sullivan, Orla (författare)
- Teagasc Moorepark Food Research Centre, Fermoy, Ireland
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- Ross, R. Paul (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland
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- Shanahan, Fergus (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland
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- Quigley, Eamonn M. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland
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- Dinan, Timothy G. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland
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- Kiely, Barry (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland
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- Fitzgerald, Gerald F. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
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- Cotter, Paul D. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland
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- Fouhy, Fiona (författare)
- Department of Microbiology, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland
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- Stanton, Catherine (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland
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(creator_code:org_t)
- Bethesda, USA : American Society for Nutrition, 2012
- 2012
- Engelska.
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Ingår i: American Journal of Clinical Nutrition. - Bethesda, USA : American Society for Nutrition. - 0002-9165 .- 1938-3207. ; 95:5, s. 1278-1287
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
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- Background: We previously showed that microbial metabolism in the gut influences the composition of bioactive fatty acids in host adipose tissue.Objective: This study compared the effect of dietary supplementation for 8 wk with human-derived Bifidobacterium breve strains on fat distribution and composition and the composition of the gut microbiota in mice.Methods: C57BL/6 mice (n = 8 per group) received B. breve DPC 6330 or B. breve NCIMB 702258 (10(9) microorganisms) daily for 8 wk or no supplement (controls). Tissue fatty acid composition was assessed by gas-liquid chromatography while 16S rRNA pyrosequencing was used to investigate microbiota composition.Results: Visceral fat mass and brain stearic acid, arachidonic acid, and DHA were higher in mice supplemented with B. breve NCIMB 702258 than in mice in the other 2 groups (P < 0.05). In addition, both B. breve DPC 6330 and B. breve NCIMB 702258 supplementation resulted in higher propionate concentrations in the cecum than did no supplementation (P < 0.05). Compositional sequencing of the gut microbiota showed a tendency for greater proportions of Clostridiaceae (25%, 12%, and 18%; P = 0.08) and lower proportions of Eubacteriaceae (3%, 12%, and 13%; P = 0.06) in mice supplemented with B. breve DPC 6330 than in mice supplemented with B. breve NCIMB 702258 and unsupplemented controls, respectively.Conclusion: The response of fatty acid metabolism to administration of bifidobacteria is strain-dependent, and strain-strain differences are important factors that influence modulation of the gut microbial community by ingested microorganisms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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Wall, Rebecca, 1 ...
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Marques, Tatiana ...
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O'Sullivan, Orla
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Ross, R. Paul
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Shanahan, Fergus
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Quigley, Eamonn ...
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Dinan, Timothy G ...
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Kiely, Barry
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Fitzgerald, Gera ...
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Cotter, Paul D.
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Fouhy, Fiona
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Stanton, Catheri ...
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