SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(O'Mahony Liam)
 

Sökning: WFRF:(O'Mahony Liam) > Recombinant lactoba...

  • Rosberg-Cody, EvaAlimentary Pharmabiotic Centre (APC), Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland (författare)

Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • Berks, United Kingdom :Society for General Microbiology,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-46363
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-46363URI
  • https://doi.org/10.1099/mic.0.043406-0DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • We have previously demonstrated that oral administration of a metabolically active Bifidobacterium breve strain, with ability to form cis-9, trans-11 conjugated linoleic acid (CLA), resulted in modulation of the fatty acid composition of the host, including significantly elevated concentrations of c9, t11 CLA and omega-3 (n-3) fatty acids in liver and adipose tissue. In this study, we investigated whether a recombinant lactobacillus expressing linoleic acid isomerase (responsible for production of t10, c12 CLA) from Propionibacterium acnes (PAI) could influence the fatty acid composition of different tissues in a mouse model. Linoleic-acid-supplemented diets (2 %, w/w) were fed in combination with either a recombinant t10, c12 CLA-producing Lactobacillus paracasei NFBC 338 (Lb338), or an isogenic (vector-containing) control strain, to BALB/c mice for 8 weeks. A third group of mice received linoleic acid alone (2 %, w/w). Tissue fatty acid composition was assessed by GLC at the end of the trial. Ingestion of the strain expressing linoleic acid isomerase was associated with a 4-fold increase (P<0.001) in t10, c12 CLA in adipose tissues of the mice when compared with mice that received the isogenic non-CLA-producing strain. The livers of the mice that received the recombinant CLA-producing Lb338 also contained a 2.5-fold (albeit not significantly) higher concentration of t10, c12 CLA, compared to the control group. These data demonstrate that a single gene (encoding linoleic acid isomerase) expressed in an intestinal microbe can influence the fatty acid composition of host fat.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Stanton, CatherineAlimentary Pharmabiotic Centre (APC), Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland (författare)
  • O'Mahony, LiamAlimentary Pharmabiotic Centre (APC), Cork, Ireland (författare)
  • Wall, Rebecca,1979-Alimentary Pharmabiotic Centre (APC), Cork, Ireland,Nutrition-Gut-Brain Interactions Research Centre(Swepub:oru)rwl (författare)
  • Shanahan, FergusAlimentary Pharmabiotic Centre (APC), Cork, Ireland (författare)
  • Quigley, Eamonn M.Alimentary Pharmabiotic Centre (APC), Cork, Ireland (författare)
  • Fitzgerald, Gerald F.Alimentary Pharmabiotic Centre (APC), Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland (författare)
  • Ross, R. PaulAlimentary Pharmabiotic Centre (APC), Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland (författare)
  • Alimentary Pharmabiotic Centre (APC), Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, IrelandAlimentary Pharmabiotic Centre (APC), Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:MicrobiologyBerks, United Kingdom : Society for General Microbiology157:2, s. 609-6151350-08721465-2080

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy