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Impact of administe...
Impact of administered bifidobacterium on murine host fatty acid composition
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- Wall, Rebecca, 1979- (författare)
- Alimentary Pharmabiotic Centre (APC), University College, Cork, Ireland,Nutrition-Gut-Brain Interactions Research Centre
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- Ross, R. Paul (författare)
- Alimentary Pharmabiotic Centre (APC), University College, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland
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- Shanahan, Fergus (författare)
- Alimentary Pharmabiotic Centre (APC), University College, Cork, Ireland, Ireland
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- O'Mahony, Liam (författare)
- Alimentary Pharmabiotic Centre (APC), University College, Cork, Ireland, Ireland
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- Kiely, Barry (författare)
- Alimentary Health (AH), University College, Cork, Ireland
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- Quigley, Eamonn (författare)
- Alimentary Pharmabiotic Centre (APC), University College, Cork, Ireland
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- Dinan, Timothy G. (författare)
- Alimentary Pharmabiotic Centre (APC), University College, Cork, Ireland
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- Fitzgerald, Gerald (författare)
- Alimentary Pharmabiotic Centre (APC), University College, Cork, Ireland; University College Cork, National University of Ireland, Cork, Ireland
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- Stanton, Catherine (författare)
- Alimentary Pharmabiotic Centre (APC), University College, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland
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(creator_code:org_t)
- 2010-04-20
- 2010
- Engelska.
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Ingår i: Lipids. - Heidelberg, Germany : Springer. - 0024-4201 .- 1558-9307. ; 45:5, s. 429-436
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Recently, we reported that administration of Bifidobacteria resulted in increased concentrations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in murine adipose tissue [1]. The objective of this study was to assess the impact of co-administration of Bifidobacterium breve NCIMB 702258 and the substrate for EPA, alpha-linolenic acid, on host fatty acid composition. alpha-Linolenic acid-supplemented diets (1%, wt/wt) were fed to mice (n = 8), with or without B. breve NCIMB 702258 (daily dose of 10(9) microorganisms) for 8 weeks. Two further groups received either supplement of B. breve alone or unsupplemented diet. Tissue fatty acid composition was assessed by gas liquid chromatography. Dietary supplementation of alpha-linolenic acid resulted in higher (P < 0.05) alpha-linolenic acid and EPA concentrations in liver and adipose tissue and lower (P < 0.05) arachidonic acid in liver, adipose tissue and brain compared with mice that did not receive alpha-linolenic acid. Supplementation with B. breve NCIMB 702258 in combination with alpha-linolenic acid resulted in elevated (P < 0.05) liver EPA concentrations compared with alpha-linolenic acid supplementation alone. Furthermore, the former group had higher (P < 0.05) DHA in brain compared with the latter group. These results suggest a role for interactions between fatty acids and commensals in the gastrointestinal tract. This interaction between administered microbes and fatty acids could result in a highly effective nutritional approach to the therapy of a variety of inflammatory and neurodegenerative conditions.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Omega-3 fatty acids
- Eicosapentaenoic acid
- Docosahexaenoic acid
- Bifidobacteria
- Microbiota
- Probiotics
Publikations- och innehållstyp
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- art (ämneskategori)
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Wall, Rebecca, 1 ...
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Ross, R. Paul
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Shanahan, Fergus
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O'Mahony, Liam
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Kiely, Barry
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Quigley, Eamonn
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Dinan, Timothy G ...
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Fitzgerald, Gera ...
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Stanton, Catheri ...
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