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Lactase persistence...
Lactase persistence versus lactose intolerance : Is there an intermediate phenotype?
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- Dzialanski, Zbigniew (author)
- University Health Care Research Center, Region Örebro County, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Barany, Michael (author)
- Department of Clinical Physiology, Örebro University Hospital, Örebro, Sweden; School of Health and Medicine Sciences, Örebro University, Örebro, Sweden
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- Engfeldt, Peter, 1947- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Region Örebro County, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Magnuson, Anders (author)
- School of Health and Medicine Sciences, Örebro University, Örebro, Sweden,Clinical Epidemiology and Biostatistics
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- Olsson, Lovisa A. (author)
- Department of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Nilsson, Torbjörn K. (author)
- Umeå universitet,Klinisk kemi
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(creator_code:org_t)
- Elsevier, 2016
- 2016
- English.
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In: Clinical Biochemistry. - : Elsevier. - 0009-9120 .- 1873-2933. ; 49:3, s. 248-252
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: According to the prevailing theory about the genetic background to lactose intolerance, there are three genotypes but only two adult physiological phenotypes: lactase persistence in individuals with the CT and TT genotypes and lactase non-persistence in individuals with the CC genotype. However, analysis of lactase activity from intestinal biopsies has revealed three distinct levels of activity, suggesting that an intermediate physiological phenotype may exist.Aim: To assess possible disparities between different genotypes with regard to biomarkers of lactase activity and physical symptoms during an oral lactose load test.Methods: A retrospective study using an oral lactose load test (n=487). Concentrations of hydrogen in exhaled air and blood glucose were measured. Afterwards, subjects were asked to provide oral mucosa samples for genotyping and answer a questionnaire (participation rate 56%, n=274).Results: Mean hydrogen levels in exhaled air at 120min were significantly higher in the CT genotype than in the TT genotype. There was no significant difference in blood glucose levels between the two groups. Reported symptoms, with the possible exception of abdominal pain, were equally prevalent in both groups.Conclusions: Subjects with the CT and TT genotypes, hitherto classified as lactase-persistent, differ in their physiological response to lactose intake, indicating differences in phenotype which could have clinical significance.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Keyword
- 13910 C/T allele
- abdominal pain
- hydrogen breath test
- oral lactose load test
Publication and Content Type
- ref (subject category)
- art (subject category)
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