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  • Andersson, ChristinKarolinska Institutet (author)

Increasing CSF phospho-tau levels during cognitive decline and progression to dementia

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Elsevier BV,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-4776
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-4776URI
  • https://doi.org/10.1016/j.neurobiolaging.2007.03.027DOI
  • https://gup.ub.gu.se/publication/96948URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-152132URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:117547618URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Little is known about longitudinal changes of cerebrospinal fluid (CSF) biomarkers during cognitive decline in neurodegenerative disease progression. OBJECTIVE: To investigate longitudinal changes in CSF biomarkers--total-tau (T-tau), phospho-tau (P-tau) and beta-amyloid (Abeta42)--during cognitive decline. METHODS: Forty memory clinic patients (47.5% females), aged 61.3+/-7.6 (S.D.) years, non-demented at baseline, underwent lumbar puncture and neuropsychological testing at two occasions. Baseline mean MMSE-score was 28.3+/-1.8. Patients were divided into three groups based on baseline memory functioning; severely impaired (SIM), moderately impaired (MIM) and no impairment (NIM). RESULTS: There was a significant increase in P-tau in the SIM-group during follow-up, while P-tau in MIM and NIM did not change. Eighty-three percent of the SIM-patients converted to dementia (80% AD), while most MIM- and NIM-patients remained non-demented. T-tau- and Abeta42-levels did not change in any of the memory groups during follow-up. CONCLUSION: Increasing P-tau levels during cognitive decline and conversion to dementia suggest that P-tau may be useful as a longitudinal marker of the neurodegenerative process.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Almkvist, OveKarolinska Institutet (author)
  • Andreasen, NielsKarolinska Institutet (author)
  • Engfeldt, PeterÖrebro universitet,Hälsoakademin(Swepub:oru)pet (author)
  • Johansson, Sven-Erik (author)
  • Lindau, MariaUppsala universitet,Geriatrik(Swepub:uu)malin088 (author)
  • Eriksdotter-Jönhagen, MariaKarolinska Institutet (author)
  • Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Neurobiology of Aging: Elsevier BV29:10, s. 1466-14730197-45801558-1497

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