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Increasing CSF phos...
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Andersson, ChristinKarolinska Institutet
(author)
Increasing CSF phospho-tau levels during cognitive decline and progression to dementia
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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Elsevier BV,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-4776
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-4776URI
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https://doi.org/10.1016/j.neurobiolaging.2007.03.027DOI
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https://gup.ub.gu.se/publication/96948URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-152132URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:117547618URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Little is known about longitudinal changes of cerebrospinal fluid (CSF) biomarkers during cognitive decline in neurodegenerative disease progression. OBJECTIVE: To investigate longitudinal changes in CSF biomarkers--total-tau (T-tau), phospho-tau (P-tau) and beta-amyloid (Abeta42)--during cognitive decline. METHODS: Forty memory clinic patients (47.5% females), aged 61.3+/-7.6 (S.D.) years, non-demented at baseline, underwent lumbar puncture and neuropsychological testing at two occasions. Baseline mean MMSE-score was 28.3+/-1.8. Patients were divided into three groups based on baseline memory functioning; severely impaired (SIM), moderately impaired (MIM) and no impairment (NIM). RESULTS: There was a significant increase in P-tau in the SIM-group during follow-up, while P-tau in MIM and NIM did not change. Eighty-three percent of the SIM-patients converted to dementia (80% AD), while most MIM- and NIM-patients remained non-demented. T-tau- and Abeta42-levels did not change in any of the memory groups during follow-up. CONCLUSION: Increasing P-tau levels during cognitive decline and conversion to dementia suggest that P-tau may be useful as a longitudinal marker of the neurodegenerative process.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Almkvist, OveKarolinska Institutet
(author)
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Andreasen, NielsKarolinska Institutet
(author)
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Engfeldt, PeterÖrebro universitet,Hälsoakademin(Swepub:oru)pet
(author)
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Johansson, Sven-Erik
(author)
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Lindau, MariaUppsala universitet,Geriatrik(Swepub:uu)malin088
(author)
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Eriksdotter-Jönhagen, MariaKarolinska Institutet
(author)
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Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
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In:Neurobiology of Aging: Elsevier BV29:10, s. 1466-14730197-45801558-1497
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