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Genomic epidemiolog...
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Demczuk, WalterBacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
(författare)
Genomic epidemiology and molecular resistance mechanisms of azithromycin resistant Neisseria gonorrhoeae in Canada from 1997 to 2014
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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Washington, USA :American Society for Microbiology,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-49205
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49205URI
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https://doi.org/10.1128/JCM.03195-15DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agency:Public Health Agency of Canada
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The emergence of Neisseria gonorrhoeae with decreased susceptibility to cephalosporins and azithromycin resistance (AZM-R) represent a public health threat of untreatable gonorrhoea infections. Genomic epidemiology through whole genome sequencing was used to describe the emergence, dissemination, and spread of AZM-R strains. The genomes of 213 AZM-R and 23 AZM-susceptible N. gonorrhoeae isolates collected in Canada from 1989 to 2014 were sequenced. Core single nucleotide polymorphism (SNP) phylogenomic analysis resolved 246 isolates into 13 lineages. High-level AZM-R (minimum inhibitory concentration ≥256 μg/ml) was found in 5 phylogenetically diverse isolates, all of which possessed the A2059G mutation (Escherichia coli numbering) in all four 23S rRNA alleles. One high-level AZM-R isolate collected in 2009 concurrently had decreased susceptibility to ceftriaxone (MIC=0.125 μg/ml). An increase in the number of 23S rRNA alleles with the C2611T mutations (E. coli numbering) conferred low to moderate AZM-R (2 to 4 and 8 to 32 μg/mL, respectively). Low level AZM-R was also associated with mtrR promoter mutations including -35A deletion and the presence of N. meningitidis-like sequences. Geographic and temporal phylogenetic clustering indicate emergent AZM-R strains arise independently and can then rapidly expand clonally in a region through local sexual networks.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Martin, IreneBacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
(författare)
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Peterson, ShelleyBacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
(författare)
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Bharat, AmritaBacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
(författare)
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Van Domselaar, GaryScience Technology Cores and Services Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
(författare)
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Graham, MoragScience Technology Cores and Services Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
(författare)
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Lefebvre, BrigitteLaboratoire de Santé Publique du Québec, Ste-Anne-de-Bellevue QC, Canada
(författare)
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Allen, VanessaPublic Health Ontario Laboratories, Toronto ON, Canada
(författare)
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Hoang, LindaBritish Columbia Centres for Disease Control Public Health Microbiology & Reference Laboratory, Vancouver BC, Canada
(författare)
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Tyrrell, GregProvincial Laboratory for Public Health, Edmonton, Canada
(författare)
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Horsman, GregSaskatchewan Disease Control Laboratory, Regina, Canada
(författare)
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Wylie, JohnCadham Provincial Laboratory, Winnipeg, Canada
(författare)
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Haldane, DavidQueen Elizabeth II Health Sciences Centre, Halifax, Canada
(författare)
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Archibald, ChrisCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Canada
(författare)
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Wong, TomFirst Nations and Inuit Health Branch, Health Canada, Ottawa, Canada
(författare)
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Unemo, Magnus,1970-Örebro universitet,Institutionen för hälsovetenskaper,Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)muo
(författare)
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Mulvey, Michael RBacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
(författare)
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Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, CanadaScience Technology Cores and Services Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Clinical MicrobiologyWashington, USA : American Society for Microbiology54:5, s. 1304-13130095-11371098-660X
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Till lärosätets databas
- Av författaren/redakt...
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Demczuk, Walter
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Martin, Irene
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Peterson, Shelle ...
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Bharat, Amrita
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Van Domselaar, G ...
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Graham, Morag
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visa fler...
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Lefebvre, Brigit ...
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Allen, Vanessa
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Hoang, Linda
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Tyrrell, Greg
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Horsman, Greg
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Wylie, John
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Haldane, David
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Archibald, Chris
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Wong, Tom
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Unemo, Magnus, 1 ...
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Mulvey, Michael ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Mikrobiologi
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Örebro universitet