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Bcl-2 immunoreactiv...
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Hellquist, H. B.Department of Pathology II, University Hospital, Linköping, Sweden
(författare)
Bcl-2 immunoreactivity in salivary gland neoplasms is unrelated to the expression of mRNA for natural killer cell stimulatory cytokines interleukin (IL)-2 and IL-12
- Artikel/kapitelEngelska1996
Förlag, utgivningsår, omfång ...
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New York, USA :Springer,1996
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-49542
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49542URI
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https://doi.org/10.1007/BF00192437DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Certain cytokines are involved in the generation of natural killer (NK) cells and participate in the regulation of the proto-oncogene bcl-2. We aimed to study the mRNA expression of interleukin (IL)-2, IL-4 and IL-5, the composition of the tumour infiltrating lymphocytes (TIL), and the expression of bcl-2 in 14 benign and malignant human parotid tumours. T IL were predominantly composed of T lymphocytes and NK cells. We found evidence for the homing of T cells, and for generation of NK cells in the vicinity of the tumours. mRNA for IL-2 and IL-12, were identified but IL-4 mRNA was not found. The cytokine profiles and the composition of TIL of the two tumour categories were indistinguishable, suggesting that these host-response variables do not explain the differences in biological behaviour of these particular tumours. The results support a shift towards Th 1 (T helper 1) cells and interferon-gamma production, and that IL-12 also in vivo may play an important role in the regulatory interaction between innate resistance and adaptive immunity in tumour diseases. Most infiltrating lymphocytes showed strong expression of bcl-2; an interesting observation with regard to lymphocytic apoptosis in neoplastic diseases. The immunoreactivity for the bcl-2 protein varied considerably between and within tumours, and almost all benign tumours showed strong bcl-2 positively whereas several of the malignant tumours showed weak or absent staining. The variable expression of bcl-2 protein suggests a different susceptibility of tumour cells to apoptosis. The results also indicate that bcl-2 cannot pla a major role as protective agent in the specific apoptotic pathway induced by NK cells.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Karlsson, Mats G.,1960-Department of Pathology, Medical Center Hospital, Örebro, Sweden(Swepub:oru)mskn
(författare)
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Karlsson, Christina,1968-Department of Pathology, Medical Center Hospital, Örebro, Sweden(Swepub:oru)ckn
(författare)
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Viale, G.Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
(författare)
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Dell'Orto, P.Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
(författare)
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Davidsson, Åke,1956-Department of Otorhinolaryngology, Medical Center Hospital, Örebro, Sweden(Swepub:oru)adn
(författare)
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Olofsson, J.Department of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, Bergen, Norway
(författare)
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Department of Pathology II, University Hospital, Linköping, SwedenDepartment of Pathology, Medical Center Hospital, Örebro, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Virchows ArchivNew York, USA : Springer429:2-3, s. 149-1580945-63171432-2307
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