Bcl-2 immunoreactivity in salivary gland neoplasms is unrelated to the expression of mRNA for natural killer cell stimulatory cytokines interleukin (IL)-2 and IL-12

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Hellquist, H. B.Department of Pathology II, University Hospital, Linköping, Sweden (författare)

Bcl-2 immunoreactivity in salivary gland neoplasms is unrelated to the expression of mRNA for natural killer cell stimulatory cytokines interleukin (IL)-2 and IL-12

Artikel/kapitelEngelska1996

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New York, USA :Springer,1996
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LIBRIS-ID:oai:DiVA.org:oru-49542
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49542URI
https://doi.org/10.1007/BF00192437DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

Anmärkningar

Certain cytokines are involved in the generation of natural killer (NK) cells and participate in the regulation of the proto-oncogene bcl-2. We aimed to study the mRNA expression of interleukin (IL)-2, IL-4 and IL-5, the composition of the tumour infiltrating lymphocytes (TIL), and the expression of bcl-2 in 14 benign and malignant human parotid tumours. T IL were predominantly composed of T lymphocytes and NK cells. We found evidence for the homing of T cells, and for generation of NK cells in the vicinity of the tumours. mRNA for IL-2 and IL-12, were identified but IL-4 mRNA was not found. The cytokine profiles and the composition of TIL of the two tumour categories were indistinguishable, suggesting that these host-response variables do not explain the differences in biological behaviour of these particular tumours. The results support a shift towards Th 1 (T helper 1) cells and interferon-gamma production, and that IL-12 also in vivo may play an important role in the regulatory interaction between innate resistance and adaptive immunity in tumour diseases. Most infiltrating lymphocytes showed strong expression of bcl-2; an interesting observation with regard to lymphocytic apoptosis in neoplastic diseases. The immunoreactivity for the bcl-2 protein varied considerably between and within tumours, and almost all benign tumours showed strong bcl-2 positively whereas several of the malignant tumours showed weak or absent staining. The variable expression of bcl-2 protein suggests a different susceptibility of tumour cells to apoptosis. The results also indicate that bcl-2 cannot pla a major role as protective agent in the specific apoptotic pathway induced by NK cells.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Klinisk laboratoriemedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Clinical Laboratory Medicine hsv//eng
Salivary gland neoplasms
cytokines
bcl-2
apoptosis
NK cells

Biuppslag (personer, institutioner, konferenser, titlar ...)

Karlsson, Mats G.,1960-Department of Pathology, Medical Center Hospital, Örebro, Sweden(Swepub:oru)mskn (författare)
Karlsson, Christina,1968-Department of Pathology, Medical Center Hospital, Örebro, Sweden(Swepub:oru)ckn (författare)
Viale, G.Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy (författare)
Dell'Orto, P.Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy (författare)
Davidsson, Åke,1956-Department of Otorhinolaryngology, Medical Center Hospital, Örebro, Sweden(Swepub:oru)adn (författare)
Olofsson, J.Department of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, Bergen, Norway (författare)
Department of Pathology II, University Hospital, Linköping, SwedenDepartment of Pathology, Medical Center Hospital, Örebro, Sweden (creator_code:org_t)

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Ingår i:Virchows ArchivNew York, USA : Springer429:2-3, s. 149-1580945-63171432-2307

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Av författaren/redakt...: Hellquist, H. B.; Karlsson, Mats G ...; Karlsson, Christ ...; Viale, G.; Dell'Orto, P.; Davidsson, Åke, ...; visa fler...; Olofsson, J.; visa färre...

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