Risk of Infections Among 2100 Individuals with IgA Deficiency: a Nationwide Cohort Study

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Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK (author)

Risk of Infections Among 2100 Individuals with IgA Deficiency : a Nationwide Cohort Study

Article/chapterEnglish2016

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2016-01-06
Springer,2016
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LIBRIS-ID:oai:DiVA.org:oru-49553
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49553URI
https://doi.org/10.1007/s10875-015-0230-9DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:133094323URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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To explore the risk of infections in individuals with IgA deficiency compared to general population controls.In this nationwide prospective population-based cohort study, we used data on IgA levels (< 0.07 g/L) from six university hospitals in Sweden to identify 2100 individuals with IgA deficiency. Individuals were diagnosed between 1980 and 2010. For each patient with IgA deficiency we identified 10 controls from the general population, matched on age, sex, and place of residence (n = 18,653). Data on infections were obtained from the Swedish National Patient Register (including inpatient and hospital-based outpatient care) between 2001 and 2010. We defined infections as having a record of a relevant international classification of disease (ICD) code. Prevalences and prevalence ratios (PRs) were calculated.Individuals with IgA deficiency were more likely to have a record of any infection (36.1 vs. 18.8 % in controls) corresponding to a PR of 2.4 (95%CI 2.2-2.6). We also noted statistically significant associations with IgA deficiency (all P-values < 0.05) and respiratory tract infections (17.8 vs. 6.3 % in controls; PR = 3.2), gastrointestinal infections (6.0 vs. 1.8 % in controls; PR = 3.5), skin infections (4.1 vs. 2.2 % in controls; PR = 1.9), joint infections (0.48 vs. 0.24 % in controls; PR = 2.0; P = 0.052), sepsis (1.5 vs. 0.45 % in controls; PR = 3.4), meningitis (0.38 vs. 0.12 %, PR = 3.2), mastoiditis/otitis (2.1 vs. 1.1 % in controls; PR = 2.0), and urinary tract infections (6.1 vs. 3.4 % in controls; PR = 1.8).Individuals with IgA deficiency are at an increased risk of infections requiring hospital care.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Immunologi inom det medicinska området hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area hsv//eng
IgA deficiency
Immunoglobulin
Infections
Immunology
Immunologi

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Neovius, MartinKarolinska Institutet (author)
Hammarström, LennartKarolinska Institutet (author)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:Journal of Clinical Immunology: Springer36:2, s. 134-1400271-91421573-2592

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