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  • Deng, JunState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China; Graduate School, the Chinese Academy of Sciences, Beijing, China (författare)

Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos

  • Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

  • Elsevier,2009
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-49990
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49990URI
  • https://doi.org/10.1016/j.aquatox.2009.03.001DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Ministry of Science and Technology of China 2006AA06Z420National Nature Science Foundation of China 20890113State Key Laboratory of Freshwater Ecology and Biotechnology 2008FBZ10
  • Hexabromocyclododecane (HBCD) is widely used as a brominated flame retardant, and has been detected in the aquatic environment, wild animals, and humans. However, details of the environmental health risk of HBCD are not well known. In this study, zebrafish embryos were used to assess the developmental toxicity of the chemical. Four-hour post-fertilization (hpf) zebrafish embryos were exposed to various concentrations of HBCD (0, 0.05, 0.1, 0.5, and 1.0 mg L-1) until 96 h. Exposure to 0.1, 0.5, and 1.0 mg L-1 HBCD significantly increased the malformation rate and reduced survival in the 0.5 and 1.0 mg L-1 HBCD exposure groups. Acridine orange (AO) staining showed that HBCD exposure resulted in cell apoptosis. Reactive oxygen species (ROS) was significantly induced at exposures of 0.1, 0.5, and 1.0 mg L-1 HBCD. To test the apoptotic pathway, several genes related to cell apoptosis, such as p53, Puma, Apaf-1, caspase-9, and caspase-3, were examined using real-time PCR. The expression patterns of these genes were up-regulated to some extent. Two anti-apoptotic genes, Mdm2 (antagonist of p53) and Bcl-2 (inhibitor of Bax), were down-regulated, and the activity of capspase-9 and caspase-3 was significantly increased. The overall results demonstrate that waterborne HBCD is able to produce oxidative stress and induce apoptosis through the involvement of caspases in zebrafish embryos. The results also indicate that zebrafish embryos can serve as a reliable model for the developmental toxicity of HBCD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Yu, LiqinState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China; Graduate School, the Chinese Academy of Sciences, Beijing, China (författare)
  • Liu, ChunshengState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China (författare)
  • Yu, KeState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China (författare)
  • Shi, XiongjieState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China (författare)
  • Yeung, Leo W. Y.,1981-Department of Biology and Chemistry, City University of Hong Kong, HK SAR, China(Swepub:oru)lyg (författare)
  • Lam, Paul K. S.Department of Biology and Chemistry, City University of Hong Kong, HK SAR, China (författare)
  • Wu, Rudolf S. S.Department of Biology and Chemistry, City University of Hong Kong, HK SAR, China (författare)
  • Zhou, BingshengState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China (författare)
  • State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China; Graduate School, the Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Aquatic Toxicology: Elsevier93:1, s. 29-360166-445X1879-1514

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