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  • Song, RenfangDepartment of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong; State Key Laboratory of Organic Geochemistry, Guangzhou Research Center of Mass Spectrometry, Guangzhou Institute of Geochemistry, Guangzhou, China; Graduate School, the Chinese Academy of Sciences, Beijing, China (författare)

Effects of fifteen PBDE metabolites, DE71, DE79 and TBBPA on steroidogenesis in the H295R cell line

  • Artikel/kapitelEngelska2008

Förlag, utgivningsår, omfång ...

  • Elsevier,2008
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-50002
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-50002URI
  • https://doi.org/10.1016/j.chemosphere.2008.01.032DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Polybrominated diphenyl ethers (PBDEs) and tetrabromobisphenol A (TBBPA) are brominated flame retardants that are produced in large quantities and are commonly used in construction materials, textiles, and as polymers in electronic equipment. Environmental and human levels of PBDEs have been increasing in the past 30 years, but the toxicity of PBDEs is not fully understood. Studies on their effects are relatively limited, and show that PBDEs are neurotoxins and potential endocrine disrupters. Hydroxylated (OH{single bond}) and methoxylated (MeO{single bond}) PBDEs have also been reported in the adipose tissue, blood and milk of wild animals and humans. In the present study, 15 PBDE metabolites, two BDE mixtures (DE71 and DE79), and TBBPA were studied individually to determine their effects on ten steroidogenic genes, aromatase activity, and concentrations of two steroid hormones (testosterone and 17β-estradiol) in the H295R human adrenocortical carcinoma cell line. Exposure to 0.05 μM 2′-OH-BDE-68 significantly induced the expression of CYP11A, CYP11B2, CYP17, CYP21, 3βHSD2, 17βHSD1, and 17βHSD4, and the expression of StAR was induced by 6-OH-BDE-90 at the three exposure concentrations. Exposure to DE71 and DE79 resulted in dose-dependent trend towards induction, but these effects were not significant. Exposure to 0.5 μM 2-OH-BDE-123 and 2-MeO-BDE-123 resulted in significantly greater aromatase activity. However, none of the compounds affected sex hormone production at the concentrations tested. Generally, OH-BDEs had a much stronger ability to affect steroidogenic gene expression than MeO-BDEs.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • He, YuheDepartment of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong (författare)
  • Murphy, Margaret B.Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong (författare)
  • Yeung, Leo W. Y.,1981-Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong(Swepub:oru)lyg (författare)
  • Yu, Richard M. K.Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong (författare)
  • Lam, Michael H. W.Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong (författare)
  • Lam, Paul K. S.Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong (författare)
  • Hecker, MarkusDepartment of Veterinary Biomedical Sciences, Toxicology Centre, University of Saskatchewan, Saskatoon, Canada; ENTRIX, Inc., RR5, Hidden Ridge Estates, Saskatoon, Canada (författare)
  • Giesy, John P.Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong; Department of Veterinary Biomedical Sciences, Toxicology Centre, University of Saskatchewan, Saskatoon, Canada; Department of Zoology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, East Lansing, MI, United States (författare)
  • Wu, Rudolf S. S.Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong (författare)
  • Zhang, WenbingState Key Laboratory of Organic Geochemistry, Guangzhou Research Center of Mass Spectrometry, Guangzhou Institute of Geochemistry, Guangzhou, China (författare)
  • Sheng, GuoyingState Key Laboratory of Organic Geochemistry, Guangzhou Research Center of Mass Spectrometry, Guangzhou Institute of Geochemistry, Guangzhou, China (författare)
  • Fu, JiamoState Key Laboratory of Organic Geochemistry, Guangzhou Research Center of Mass Spectrometry, Guangzhou Institute of Geochemistry, Guangzhou, China (författare)
  • Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong; State Key Laboratory of Organic Geochemistry, Guangzhou Research Center of Mass Spectrometry, Guangzhou Institute of Geochemistry, Guangzhou, China; Graduate School, the Chinese Academy of Sciences, Beijing, ChinaDepartment of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Chemosphere: Elsevier71:10, s. 1888-18940045-65351879-1298

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