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Early detection of ...
Early detection of type 2 diabetes mellitus and screening for retinopathy are associated with reduced prevalence and severity of retinopathy
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- Olafsdottir, Eydis (författare)
- Department of Ophthalmology, The National University Hospital, Reykjavik, Iceland; University of Iceland, Reykjavik, Iceland; Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden,Natl Univ Hosp Reykjavik, Dept Ophthalmol, Reykjavik, Iceland.;Univ Iceland, Reykjavik, Iceland.;Orebro Univ Hosp, Dept Ophthalmol, S-70116 Orebro, Sweden.
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- Andersson, Dan K. G. (författare)
- Uppsala universitet,Allmänmedicin och preventivmedicin
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- Dedorsson, Inger (författare)
- Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Dept Ophthalmol, S-70116 Orebro, Sweden.
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- Svärdsudd, Kurt (författare)
- Uppsala universitet,Allmänmedicin och preventivmedicin
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- Jansson, Stefan P O, 1959- (författare)
- Uppsala universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Family Medicine and Preventive Medicine Section, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden; Family Medicine Research Centre, Örebro County Council, Örebro, Sweden,Allmänmedicin och preventivmedicin,Univ Orebro, Sch Hlth & Med Sci, Orebro Cty Council, Family Med Res Ctr, S-31705 Orebro, Sweden.
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- Stefánsson, Einar (författare)
- Department of Ophthalmology, The National University Hospital, Reykjavik, Iceland; University of Iceland, Reykjavik, Iceland,Natl Univ Hosp Reykjavik, Dept Ophthalmol, Reykjavik, Iceland.;Univ Iceland, Reykjavik, Iceland.
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Department of Ophthalmology, The National University Hospital, Reykjavik, Iceland; University of Iceland, Reykjavik, Iceland; Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden Natl Univ Hosp Reykjavik, Dept Ophthalmol, Reykjavik, Iceland;Univ Iceland, Reykjavik, Iceland.;Orebro Univ Hosp, Dept Ophthalmol, S-70116 Orebro, Sweden. (creator_code:org_t)
- 2016-02-08
- 2016
- Engelska.
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Ingår i: Acta Ophthalmologica. - Hoboken, USA : Wiley-Blackwell Publishing Inc.. - 1755-375X .- 1755-3768. ; 94:3, s. 232-239
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Purpose: To explore whether the prevalence and severity of retinopathy differ in diabetes cohorts diagnosed through screening as compared with conventional health care.Methods: A total of 257 diabetes patients, 151 detected through screening and 106 through conventional clinical care, were included. Retinopathy was evaluated by fundus photography. The modified Airlie House adaptation of the Early Treatment Retinopathy Study protocol was used to grade the photographs. Averages of clinically collected fasting blood glucose (FBG), blood pressure and body mass index values were compiled from diabetes diagnosis until the eye examination. Blood chemistry, smoking habits and peripheral neuropathy were assessed at the time of the eye examination.Results: Among the screening-detected patients, 22% had retinopathy as compared to 51% among those clinically detected (p < 0.0001). In a multivariate analysis, patients with retinopathy were more likely to have increased average FBG (OR 1.42, 95% CI 1.19-1.70 per mmol/l) and peripheral neuropathy (OR 2.75, 95% CI 1.40-5.43), but less likely to have screening-detected diabetes (OR 0.31, 95% CI 0.17-0.57). Similar results were found using increasing severity grade of retinopathy as outcome. The cumulative retinopathy prevalence for the screening-detected diabetes cohort as compared with the clinically diagnosed cohort was significantly lower from 10 years' follow-up and onwards (p = 0.0002).Conclusions: Among patients with screening-detected diabetes, the prevalence of retinopathy and increasing severity of retinopathy were significantly lower than among those who had their diabetes diagnosed through conventional care, even when other risk factors for retinopathy such as duration, hyperglycaemia and blood pressure were considered. Early detection of diabetes reduces prediagnostic time spent with hyperglycaemia. In combination with early and regular screening for retinopathy, more effective prevention against retinopathy can be provided.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Diabetes duration
- longitudinal data
- opportunistic case finding
- peripheral neuropathy
- retinopathy
- screening
- type 2 diabetes mellitus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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