Sökning: id:"swepub:oai:DiVA.org:oru-50441" >
NLRP3 Inflammasome ...
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Paramel Varghese, Geena,1985-Örebro universitet,Institutionen för medicinska vetenskaper
(författare)
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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Hoboken, USA :Wiley-Blackwell Publishing Inc.2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-50441
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-50441URI
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https://doi.org/10.1161/JAHA.115.003031DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134501125URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies:Center of Excellence for Research on Inflammation and Cardiovascular Disease (CERIC) Linnaeus Center8703Foundation for Strategic Research, Uppdrag Besegra Stroke P581/2011-123Strategic Cardiovascular Programs of Karolinska Institutet, Stockholm County Council ALF 20110279Örebro UniversitySigurd and Elsa Goljes Foundation
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Background: The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)-1β and IL-18 cytokine processing complex that is activated in inflammatory conditions. The role of the NLRP3 inflammasome in the pathogenesis of atherosclerosis and myocardial infarction is not fully understood.Methods and Results: Atherosclerotic plaques were analyzed for transcripts of the NLRP3 inflammasome, and for IL-1β release. The Swedish First-ever myocardial Infarction study in Ac-county (FIA) cohort consisting of DNA from 555 myocardial infarction patients and 1016 healthy individuals was used to determine the frequency of 4 single nucleotide polymorphisms (SNPs) from the downstream regulatory region of NLRP3. Expression of NLRP3, Apoptosis-associated speck-like protein containing a CARD (ASC), caspase-1 (CASP1), IL1B, and IL18 mRNA was significantly increased in atherosclerotic plaques compared to normal arteries. The expression of NLRP3 mRNA was significantly higher in plaques of symptomatic patients when compared to asymptomatic ones. CD68-positive macrophages were observed in the same areas of atherosclerotic lesions as NLRP3 and ASC expression. Occasionally, expression of NLRP3 and ASC was also present in smooth muscle cells. Cholesterol crystals and ATP induced IL-1β release from lipopolysaccharide-primed human atherosclerotic lesion plaques. The minor alleles of the variants rs4266924, rs6672995, and rs10733113 were associated with NLRP3 mRNA levels in peripheral blood mononuclear cells but not with the risk of myocardial infarction.Conclusions: Our results indicate a possible role of the NLRP3 inflammasome and its genetic variants in the pathogenesis of atherosclerosis.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Folkersen, LasseDepartment of Medicine and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
(författare)
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Strawbridge, Rona J.Karolinska Institutet
(författare)
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Halvorsen, BenteResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
(författare)
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Yndestad, ArneResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway
(författare)
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Ranheim, TrineResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
(författare)
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Krohg-Sørensen, KirstenDepartment of Thoracic and Cardiovascular Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway
(författare)
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Skjelland, MonaDepartment of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway
(författare)
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Espevik, TerjeCentre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway
(författare)
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Aukrust, PålResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway
(författare)
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Lengquist, MarietteKarolinska Institutet
(författare)
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Hedin, UlfKarolinska Institutet
(författare)
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Jansson, Jan-HåkanDepartment of Internal Medicine, Umeå University Hospital, Umeå, Sweden; Department of Internal Medicine, Skellefteå Hospital, Skellefteå, Sweden
(författare)
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Fransén, Karin,1973-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)kifn
(författare)
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Hansson, Göran K.Karolinska Institutet
(författare)
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Eriksson, PerKarolinska Institutet
(författare)
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Sirsjö, Allan,1959-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)aso
(författare)
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Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of the American Heart AssociationHoboken, USA : Wiley-Blackwell Publishing Inc.5:52047-9980
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Paramel Varghese ...
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Folkersen, Lasse
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Strawbridge, Ron ...
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Halvorsen, Bente
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Yndestad, Arne
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Ranheim, Trine
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visa fler...
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Krohg-Sørensen, ...
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Skjelland, Mona
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Espevik, Terje
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Aukrust, Pål
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Lengquist, Marie ...
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Hedin, Ulf
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Jansson, Jan-Håk ...
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Fransén, Karin, ...
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Hansson, Göran K ...
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Eriksson, Per
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Sirsjö, Allan, 1 ...
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