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  • Andrén, Ove,1963-Örebro universitet,Hälsoakademin (author)

MUC-1 gene is associated with prostate cancer death : a 20-year follow-up of a population-based study in Sweden

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2007-08-28
  • London :Harcourt Publishers,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-5063
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-5063URI
  • https://doi.org/10.1038/sj.bjc.6603944DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:115811632URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Anti-adhesion mucins have proven to play an important part in the biology of several types of cancer. Therefore, we test the hypothesis that altered expression of MUC-1 is associated with prostate cancer progression. We retrieved archival tumour tissue from a population-based cohort of 195 men with localised prostate cancer (T1a-b, Nx, M0) that has been followed for up to 20 years with watchful waiting. Semi-automated, quantitative immunohistochemistry was undertaken to evaluate MUC-1 expression. We modelled prostate cancer-specific death as a function of MUC-1 levels accounting for age, Gleason grade and tumour extent, and calculated age-adjusted and multivariate adjusted hazard ratios (HR). Men that had tumours with an MUC-intensity lower or higher than normal tissue had a higher risk of dying in prostate cancer, independent of tumour extent and Gleason score (HR 5.1 and 4.5, respectively). Adjustment for Gleason grade and tumour stage did not alter the results. Men with a Gleason score >=7 and MUC-1 deviating from the normal had a 17 (RR=17.1 95% confidence interval=2.3–128) times higher risk to die in prostate cancer compared with men with Gleason score <7 and normal MUC-1 intensity. In summary, our data show that MUC-1 is an independent prognostic marker for prostate cancer death.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fall, KatjaKarolinska Institutet (author)
  • Andersson, Swen-Olof (author)
  • Rubin, Mark A. (author)
  • Bismar, Tarek A. (author)
  • Karlsson, M. (author)
  • Johansson, Jan-ErikÖrebro universitet,Hälsoakademin(Swepub:oru)jkjn (author)
  • Mucci, Lorelei A. (author)
  • Örebro universitetHälsoakademin (creator_code:org_t)

Related titles

  • In:British Journal of CancerLondon : Harcourt Publishers97:6, s. 730-7340007-09201532-1827

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