Sökning: WFRF:(Andrén Ove 1963 )
> (2015-2019) >
Frequency and typin...
-
Davidsson, Sabina,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology, Örebro University Hospital, Örebro, Sweden,Transdisciplinary Prostate Cancer Partnership (TopCaP)
(författare)
Frequency and typing of Propionibacterium acnes in prostate tissue obtained from men with and without prostate cancer
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
-
2016-06-09
-
London, United Kingdom :BioMed Central (BMC),2016
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:oru-50868
-
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-50868URI
-
https://doi.org/10.1186/s13027-016-0074-9DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123434URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
The erratum to this article has been published in Infectious Agents and Cancer 2016 11:36.Funding Agencies:Örebro County Council Research CommitteeFoundation for Medical Research at Örebro University Hospital, Sweden
-
Background: Prostate cancer is the most common cancer among men in Western countries but the exact pathogenic mechanism of the disease is still largely unknown. An infectious etiology and infection-induced inflammation has been suggested to play a role in prostate carcinogenesis and Propionibacterium acnes has been reported as the most prevalent microorganism in prostatic tissue. We investigated the frequency and types of P. acnes isolated from prostate tissue samples from men with prostate cancer and from control patients without the disease.Methods: We included 100 cases and 50 controls in this study. Cases were men diagnosed with prostate cancer undergoing radical prostatectomy and controls were men undergoing surgery for bladder cancer without any histological findings of prostate cancer. Six biopsies taken from each patient's prostate gland at the time of surgery were used for cultivation and further characterization of P. acnes.Results: The results revealed that P. acnes was more common in men with prostate carcinoma than in controls, with the bacteria cultured in 60 % of the cases vs. 26 % of the controls (p = 0.001). In multivariable analyses, men with P. acnes had a 4-fold increase in odds of a prostate cancer diagnosis after adjustment for age, calendar year of surgery and smoking status (OR: 4.46; 95 % CI: 1.93-11.26). To further support the biologic plausibility for a P. acnes infection as a contributing factor in prostate cancer development, we subsequently conducted cell-based experiments. P. acnes- isolates were co-cultured with the prostate cell line PNT1A. An increased cell proliferation and cytokine/chemokine secretion in infected cells was observed.Conclusion: The present study provides further evidence for a role of P. acnes in prostate cancer development.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Mölling, PaulaDepartment of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden
(författare)
-
Rider, Jennifer R.Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA,Transdisciplinary Prostate Cancer Partnership (TopCaP)
(författare)
-
Unemo, Magnus,1970-Örebro universitet,Institutionen för hälsovetenskaper,Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)muo
(författare)
-
Karlsson, Mats G.,1960-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Pathology, Örebro University Hospital, Örebro, Sweden; Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)mskn
(författare)
-
Carlsson, Jessica,1984-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology, Örebro University Hospital, Örebro, Sweden,Transdisciplinary Prostate Cancer Partnership (TopCaP)(Swepub:oru)jccn
(författare)
-
Andersson, Swen-Olof,1949-Örebro universitet,Institutionen för hälsovetenskaper,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Transdisciplinary Prostate Cancer Partnership (TopCaP)(Swepub:oru)sfan
(författare)
-
Elgh, FredrikUmeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)frkelh76
(författare)
-
Söderquist, Bo,1955-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)bost
(författare)
-
Andrén, Ove,1963-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology, Örebro University Hospital, Örebro, Sweden,Transdisciplinary Prostate Cancer Partnership (TopCaP)(Swepub:oru)oan
(författare)
-
Örebro universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Infectious Agents and CancerLondon, United Kingdom : BioMed Central (BMC)111750-9378
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Davidsson, Sabin ...
-
Mölling, Paula
-
Rider, Jennifer ...
-
Unemo, Magnus, 1 ...
-
Karlsson, Mats G ...
-
Carlsson, Jessic ...
-
visa fler...
-
Andersson, Swen- ...
-
Elgh, Fredrik
-
Söderquist, Bo, ...
-
Andrén, Ove, 196 ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Urologi och njur ...
- Artiklar i publikationen
-
Infectious Agent ...
- Av lärosätet
-
Örebro universitet
-
Umeå universitet