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Associations betwee...
Associations between the FKBP5 haplotype, exposure to violence and anxiety in females
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- Isaksson, Johan (author)
- Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst, Ctr Neurodev Disorders, Karolinska Inst KIND, Dept Womens & Childrens Hlth,Pediat Neuropsychiat, S-17177 Stockholm, Sweden
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- Comasco, Erika (author)
- Uppsala universitet,Neuropsykofarmakologi
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- Åslund, Cecilia (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Rehn, Mattias (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Tuvblad, Catherine, 1968- (author)
- Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Department of Psychology, University of Southern California, Los Angeles, USA,Univ Southern Calif, Dept Psychol, Los Angeles, CA 90089 USA.;Univ Orebro, Sch Law Psychol & Social Work, S-70182 Orebro, Sweden.,Department of Psychology, University of Southern California, CA 90089-1061, USA;School of Law, Psychology and Social Work, Örebro University, 701 82 Örebro, Sweden
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- Andershed, Henrik, 1975- (author)
- Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Univ Orebro, Sch Law Psychol & Social Work, S-70182 Orebro, Sweden.,School of Law, Psychology and Social Work, Örebro University, 701 82 Örebro, Sweden
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- Nilsson, Kent W. (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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(creator_code:org_t)
- Oxford, United Kingdom : Elsevier, 2016
- 2016
- English.
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In: Psychoneuroendocrinology. - Oxford, United Kingdom : Elsevier. - 0306-4530 .- 1873-3360. ; 72, s. 196-204
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Abstract
Subject headings
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- The gene that encodes the FK506-binding protein 5 (FKBP5) is regarded as a candidate for investigating how negative life events interact with a genetic predisposition to stress-related disorders, such as depression and anxiety. Given the role of FKBP5 as an important regulator of stress responses, we aimed to investigate if single-nucleotide polymorphisms (SNPs) in FKBP5-in the presence/absence of exposure to violence-are associated with symptoms of depression and anxiety. Data from two community-based samples of adolescents (n=1705) and young adults (n=1800) regarding ratings on depression, anxiety, exposure to violence and FKBP5 genotype were collected. A risk haplogenotype including the minor alleles of seven common SNPs in the FKBP5 (rs3800373, rs9296158, rs7748266, rs1360780, rs9394309, rs9470080 and rs4713916) conferred higher ratings on anxiety among females, but not males, in the presence of violence. Exposure to violence and female sex were associated with higher ratings on both depression and anxiety, with the exception of ratings on depression among young adults, on which sex had no effect. Ratings on depression were not associated with the haplogenotype. These findings may correspond to differences in the regulation of the HPA axis and with the higher vulnerability to anxiety in females.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- FKBP5
- anxiety
- depression
- exposure to violence
- sex differences
- Psychiatry
- Psykiatri
- Neurology
- Neurologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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