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  • Di Paolo, CarolinaInstitute for Environmental Research, RWTH Aachen University, Aachen, Germany (author)

Bioassay battery interlaboratory investigation of emerging contaminants in spikedwater extracts : Towards the implementation of bioanalytical monitoring tools inwater quality assessment and monitoring

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Elsevier,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-52050
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-52050URI
  • https://doi.org/10.1016/j.watres.2016.08.018DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-136275URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:European Marie Curie Initial Training Network EDA-EMERGE 290100European FP7 Collaborative Project SOLUTIONS 603437NORMAN AssociationEDA-EMERGE Marie Curie ITN ESR1French Ministry of Ecology P181ONEMA
  • Bioassays are particularly useful tools to link the chemical and ecological assessments in water quality monitoring. Different methods cover a broad range of toxicity mechanisms in diverse organisms, and account for risks posed by non-target compounds and mixtures. Many tests are already applied in chemical and waste assessments, and stakeholders from the science-police interface have recommended their integration in regulatory water quality monitoring. Still, there is a need to address bioassay suitability to evaluate water samples containing emerging pollutants, which are a current priority in water quality monitoring. The presented interlaboratory study (ILS) verified whether a battery of miniaturized bioassays, conducted in 11 different laboratories following their own protocols, would produce comparable results when applied to evaluate blinded samples consisting of a pristine water extract spiked with four emerging pollutants as single chemicals or mixtures, i.e. triclosan, acridine, 17α-ethinylestradiol (EE2) and 3-nitrobenzanthrone (3-NBA). Assays evaluated effects on aquatic organisms from three different trophic levels (algae, daphnids, zebrafish embryos) and mechanism-specific effects using in vitro estrogenicity (ER-Luc, YES) and mutagenicity (Ames fluctuation) assays. The test battery presented complementary sensitivity and specificity to evaluate the different blinded water extract spikes. Aquatic organisms differed in terms of sensitivity to triclosan (algae > daphnids > fish) and acridine (fish > daphnids > algae) spikes, confirming the complementary role of the three taxa for water quality assessment. Estrogenicity and mutagenicity assays identified with high precision the respective mechanism-specific effects of spikes even when non-specific toxicity occurred in mixture. For estrogenicity, although differences were observed between assays and models, EE2 spike relative induction EC50 values were comparable to the literature, and E2/EE2 equivalency factors reliably reflected the sample content. In the Ames, strong revertant induction occurred following 3-NBA spike incubation with the TA98 strain, which was of lower magnitude after metabolic transformation and when compared to TA100. Differences in experimental protocols, model organisms, and data analysis can be sources of variation, indicating that respective harmonized standard procedures should be followed when implementing bioassays in water monitoring. Together with other ongoing activities for the validation of a basic bioassay battery, the present study is an important step towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring.

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  • Ottermanns, RichardInstitute for Environmental Research, RWTH Aachen University, Aachen, GermanyWTH Aachen University, Aachen, Germany (author)
  • Keiter, Steffen,1971-Örebro universitet,Institutionen för naturvetenskap och teknik,Institute for Environmental Research, RWTH Aachen University, Aachen, Germany,MTM(Swepub:oru)sfkr (author)
  • Ait-Aissa, SelimINERIS, Verneuil-en-Halatte, France (author)
  • Bluhm, KerstinInstitute for Environmental Research, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany (author)
  • Brack, WernerUFZ-Helmholtz Centre for Environmental Research, Leipzig, Germany (author)
  • Breitholtz, MagnusStockholms universitet,Institutionen för tillämpad miljövetenskap (ITM)(Swepub:su)breit (author)
  • Buchinger, SebastianDepartment Biochemistry and Ecotoxicology, Federal Institute of Hydrology, Koblenz, Germany (author)
  • Carere, MarioItalian Institute of Health, Rome, Italy (author)
  • Chalon, CaroleISSeP (Scienti fi c Institute of Public Service), Liège, Belgium (author)
  • Cousin, XavierLaboratoire d'Ecotoxicologie, L'Institut Français de Recherche pour l'Exploitation de la Mer (Ifremer), L'Houmeau, France; Laboratoire de Physiologie et Génétique des Poissons, Inra, Rennes, France (author)
  • Dulio, ValeriaInstitut national de l'environnement industriel et des risques (INERIS), Verneuil-en-Halatte, France (author)
  • Escher, BeateUFZ-Helmholtz Centre for Environmental Research, Leipzig, Germany; National Research Centre for Environmental Toxicology - Entox, The University of Queensland, Brisbane, Australia; Centre for Applied Geosciences, Eberhard Karls University, Tübingen, Germany (author)
  • Hamers, TimoInstitute for Environmental Studies -IVM, Vrije University, Amsterdam, The Netherlands (author)
  • Hilscherová, KlaraResearch Centre for Toxic Compounds in the Environment - RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic (author)
  • Jarque, SergioResearch Centre for Toxic Compounds in the Environment - RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic (author)
  • Jonas, AdamResearch Centre for Toxic Compounds in the Environment - RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic (author)
  • Maillot-Marechal, EmmanuelleInstitut national de l'environnement industriel et des risques (INERIS), Verneuil-en-Halatte, France (author)
  • Marneffe, YvesISSeP (Scienti fi c Institute of Public Service), Liège, Wallonia, Belgium (author)
  • Nguyen, Mai ThaoWaterproef Laboratory, Edam, The Netherlands (author)
  • Pandard, PascalINERIS, Verneuil-en-Halatte, France (author)
  • Schifferli, AndreaSwiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland (author)
  • Schulze, TobiasUFZ-Helmholtz Centre for Environmental Research, Leipzig, Germany (author)
  • Seidensticker, SvenInstitute for Environmental Research, RWTH Aachen University, Aachen, Germany; Laboratoire d'Ecotoxicologie, Ifremer, L'Houmeau, France (author)
  • Seiler, Thomas B.Institute for Environmental Research, RWTH Aachen University, Aachen, Germany (author)
  • Tang, JanetNational Research Centre for Environmental Toxicology - Entox, The University of Queensland, Brisbane, Australia (author)
  • van der Oost, RonWATERNET Institute for the Urban Water Cycle, Division of Technology Research & Engineering, Amsterdam, The Netherlands (author)
  • Vermeirssen, EtienneSwiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland (author)
  • Zounková, RadkaResearch Centre for Toxic Compounds in the Environment - RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic (author)
  • Zwart, NickInstitute for Environmental Studies -IVM, Vrije University, Amsterdam, The Netherlands (author)
  • Hollert, HennerInstitute for Environmental Research, RWTH Aachen University, Aachen, Germany (author)
  • Institute for Environmental Research, RWTH Aachen University, Aachen, GermanyInstitute for Environmental Research, RWTH Aachen University, Aachen, GermanyWTH Aachen University, Aachen, Germany (creator_code:org_t)

Related titles

  • In:Water Research: Elsevier104, s. 473-4840043-13541879-2448

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