Bioassay battery interlaboratory investigation of emerging contaminants in spikedwater extracts: Towards the implementation of bioanalytical monitoring tools inwater quality assessment and monitoring

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Bioassay battery interlaboratory investigation of emerging contaminants in spikedwater extracts : Towards the implementation of bioanalytical monitoring tools inwater quality assessment and monitoring

Di Paolo, Carolina (författare): Institute for Environmental Research, RWTH Aachen University, Aachen, Germany

Ottermanns, Richard (författare): Institute for Environmental Research, RWTH Aachen University, Aachen, GermanyWTH Aachen University, Aachen, Germany

Keiter, Steffen, 1971- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,Institute for Environmental Research, RWTH Aachen University, Aachen, Germany,MTM

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Ait-Aissa, Selim (författare): INERIS, Verneuil-en-Halatte, France

Bluhm, Kerstin (författare): Institute for Environmental Research, Rheinisch-Westfälische Technische Hochschule, Aachen, Germany

Brack, Werner (författare): UFZ-Helmholtz Centre for Environmental Research, Leipzig, Germany

Breitholtz, Magnus (författare): Stockholms universitet,Institutionen för tillämpad miljövetenskap (ITM)

Buchinger, Sebastian (författare): Department Biochemistry and Ecotoxicology, Federal Institute of Hydrology, Koblenz, Germany

Carere, Mario (författare): Italian Institute of Health, Rome, Italy

Chalon, Carole (författare): ISSeP (Scienti fi c Institute of Public Service), Liège, Belgium

Cousin, Xavier (författare): Laboratoire d'Ecotoxicologie, L'Institut Français de Recherche pour l'Exploitation de la Mer (Ifremer), L'Houmeau, France; Laboratoire de Physiologie et Génétique des Poissons, Inra, Rennes, France

Dulio, Valeria (författare): Institut national de l'environnement industriel et des risques (INERIS), Verneuil-en-Halatte, France

Escher, Beate (författare): UFZ-Helmholtz Centre for Environmental Research, Leipzig, Germany; National Research Centre for Environmental Toxicology - Entox, The University of Queensland, Brisbane, Australia; Centre for Applied Geosciences, Eberhard Karls University, Tübingen, Germany

Hamers, Timo (författare): Institute for Environmental Studies -IVM, Vrije University, Amsterdam, The Netherlands

Hilscherová, Klara (författare): Research Centre for Toxic Compounds in the Environment - RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic

Jarque, Sergio (författare): Research Centre for Toxic Compounds in the Environment - RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic

Jonas, Adam (författare): Research Centre for Toxic Compounds in the Environment - RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic

Maillot-Marechal, Emmanuelle (författare): Institut national de l'environnement industriel et des risques (INERIS), Verneuil-en-Halatte, France

Marneffe, Yves (författare): ISSeP (Scienti fi c Institute of Public Service), Liège, Wallonia, Belgium

Nguyen, Mai Thao (författare): Waterproef Laboratory, Edam, The Netherlands

Pandard, Pascal (författare): INERIS, Verneuil-en-Halatte, France

Schifferli, Andrea (författare): Swiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland

Schulze, Tobias (författare): UFZ-Helmholtz Centre for Environmental Research, Leipzig, Germany

Seidensticker, Sven (författare): Institute for Environmental Research, RWTH Aachen University, Aachen, Germany; Laboratoire d'Ecotoxicologie, Ifremer, L'Houmeau, France

Seiler, Thomas B. (författare): Institute for Environmental Research, RWTH Aachen University, Aachen, Germany

Tang, Janet (författare): National Research Centre for Environmental Toxicology - Entox, The University of Queensland, Brisbane, Australia

van der Oost, Ron (författare): WATERNET Institute for the Urban Water Cycle, Division of Technology Research & Engineering, Amsterdam, The Netherlands

Vermeirssen, Etienne (författare): Swiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland

Zounková, Radka (författare): Research Centre for Toxic Compounds in the Environment - RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic

Zwart, Nick (författare): Institute for Environmental Studies -IVM, Vrije University, Amsterdam, The Netherlands

Hollert, Henner (författare): Institute for Environmental Research, RWTH Aachen University, Aachen, Germany

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Elsevier, 2016
2016
Engelska.
Ingår i: Water Research. - : Elsevier. - 0043-1354 .- 1879-2448. ; 104, s. 473-484

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Bioassays are particularly useful tools to link the chemical and ecological assessments in water quality monitoring. Different methods cover a broad range of toxicity mechanisms in diverse organisms, and account for risks posed by non-target compounds and mixtures. Many tests are already applied in chemical and waste assessments, and stakeholders from the science-police interface have recommended their integration in regulatory water quality monitoring. Still, there is a need to address bioassay suitability to evaluate water samples containing emerging pollutants, which are a current priority in water quality monitoring. The presented interlaboratory study (ILS) verified whether a battery of miniaturized bioassays, conducted in 11 different laboratories following their own protocols, would produce comparable results when applied to evaluate blinded samples consisting of a pristine water extract spiked with four emerging pollutants as single chemicals or mixtures, i.e. triclosan, acridine, 17α-ethinylestradiol (EE2) and 3-nitrobenzanthrone (3-NBA). Assays evaluated effects on aquatic organisms from three different trophic levels (algae, daphnids, zebrafish embryos) and mechanism-specific effects using in vitro estrogenicity (ER-Luc, YES) and mutagenicity (Ames fluctuation) assays. The test battery presented complementary sensitivity and specificity to evaluate the different blinded water extract spikes. Aquatic organisms differed in terms of sensitivity to triclosan (algae > daphnids > fish) and acridine (fish > daphnids > algae) spikes, confirming the complementary role of the three taxa for water quality assessment. Estrogenicity and mutagenicity assays identified with high precision the respective mechanism-specific effects of spikes even when non-specific toxicity occurred in mixture. For estrogenicity, although differences were observed between assays and models, EE2 spike relative induction EC50 values were comparable to the literature, and E2/EE2 equivalency factors reliably reflected the sample content. In the Ames, strong revertant induction occurred following 3-NBA spike incubation with the TA98 strain, which was of lower magnitude after metabolic transformation and when compared to TA100. Differences in experimental protocols, model organisms, and data analysis can be sources of variation, indicating that respective harmonized standard procedures should be followed when implementing bioassays in water monitoring. Together with other ongoing activities for the validation of a basic bioassay battery, the present study is an important step towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring.

Ämnesord

NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
TEKNIK OCH TEKNOLOGIER -- Naturresursteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY -- Environmental Engineering (hsv//eng)

Nyckelord

Triclosan
Acridine
17α-ethinylestradiol
3-Nitrobenzanthrone
Organism-level toxicity
Mechanism-specific toxicity
Enviromental Science
Miljövetenskap

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Av lärosätet: Örebro universitet; Stockholms universitet

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