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  • Welinder, Karen GjesingDepartment of Chemistry and Bioscience, Section of Biotechnology, Aalborg University, Aalborg, Denmark (author)

Biochemical Foundations of Health and Energy Conservation in Hibernating Free-Ranging Subadult Brown Bear Ursus arctos

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • Rockville, USA :American Society for Biochemistry and Molecular Biology,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-52176
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-52176URI
  • https://doi.org/10.1074/jbc.M116.742916DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132848URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agency:Lundbech Foundation R126-2012-12408Aalborg University
  • Funding Agencies|Lundbech Foundation [R126-2012-12408]; Aalborg University
  • Brown bears (Ursus arctos) hibernate for 5-7 months without eating, drinking, urinating and defecating at a metabolic rate of only 25% of the summer activity rate. Nonetheless, they emerge healthy and alert in spring. We quantified the biochemical adaptations for hibernation by comparing the proteome, metabolome, and hematologic features of blood from hibernating and active free-ranging subadult brown bears with a focus on conservation of health and energy. We found that total plasma protein concentration increased during hibernation, even though the concentrations of most individual plasma proteins decreased, as did the white blood cell types. Strikingly, antimicrobial defense proteins increased in concentration. Central functions in hibernation involving the coagulation response and protease inhibition, as well as lipid transport and metabolism, were upheld by increased levels of very few key or broad-specificity proteins. The changes in coagulation factor levels matched the changes in activity measurements. A dramatic 45-fold increase in sex-hormone-binding-globulin SHBG levels during hibernation draws, for the first time, attention to its significant but unknown role in maintaining hibernation physiology. We propose that energy for the costly protein synthesis is reduced by three mechanisms, (i) dehydration, which increases protein concentration without de novo synthesis; (ii) reduced protein degradation rates due to a 6 °C reduction in body temperature, and decreased protease activity; and (iii) a marked redistribution of energy resources only increasing de novo synthesis of few key proteins. This comprehensive global data identified novel biochemical strategies for bear adaptations to the extreme condition of hibernation, and have implications for our understanding of physiology in general.

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  • Hansen, RasmusDepartment of Chemistry and Bioscience, Section of Biotechnology, Aalborg University, Aalborg, Denmark; Wellspring Biosciences LLC, San Diego CA, United States (author)
  • Overgaard, Michael ToftDepartment of Chemistry and Bioscience, Section of Biotechnology, Aalborg University, Aalborg, Denmark (author)
  • Brohus, MaleneDepartment of Chemistry and Bioscience, Section of Biotechnology, Aalborg University, Aalborg, Denmark (author)
  • Sønderkær, MadsDepartment of Chemistry and Bioscience, Section of Biotechnology, Aalborg University, Aalborg, Denmark (author)
  • von Bergen, MartinDepartment of Chemistry and Bioscience, Section of Biotechnology, Aalborg University, Aalborg, Denmark; Department of Metabolomics, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany; Department of Proteomics, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany,Aalborg University, Denmark; UFZ Helmholtz Centre Environm Research, Germany; UFZ Helmholtz Centre Environm Research, Germany (author)
  • Rolle-Kampczyk, UlrikeDepartment of Metabolomics, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany,UFZ Helmholtz Centre Environm Research, Germany (author)
  • Otto, WolfgangDepartment of Proteomics, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany,UFZ Helmholtz Centre Environm Research, Germany (author)
  • Lindahl, TomasLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk kemi(Swepub:liu)tomli13 (author)
  • Arinell, Karin,1982-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Örebro University Hospital, Örebro, Sweden(Swepub:oru)kal (author)
  • Evans, Alina L.Department of Forestry and Wildlife Management, Hedmark University College Evenstrand, Elverum, Norway,Hedmark University of Coll, Norway (author)
  • Swenson, Jon E.Department for Ecology and Natural Resource Management, Norwegian University of Life Sciences, Ås, Norway; Norwegian Institute for Nature Research, Trondheim, Norway,Norwegian University of Life Science, Norway; Norwegian Institute Nat Research, Norway (author)
  • Revsbech, Inge G.Department of Bioscience, Zoophysiology, Aarhus University, Aarhus, Denmark (author)
  • Fröbert, Ole,1964-Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden(Swepub:oru)oft (author)
  • Department of Chemistry and Bioscience, Section of Biotechnology, Aalborg University, Aalborg, DenmarkDepartment of Chemistry and Bioscience, Section of Biotechnology, Aalborg University, Aalborg, Denmark; Wellspring Biosciences LLC, San Diego CA, United States (creator_code:org_t)

Related titles

  • In:Journal of Biological ChemistryRockville, USA : American Society for Biochemistry and Molecular Biology291:43, s. 22509-225230021-92581083-351X

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