Risk of primary adrenal insufficiency in patients with celiac disease

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MARC

Elfström, Peter,1974-Örebro universitet,Hälsoakademin (author)

Risk of primary adrenal insufficiency in patients with celiac disease

Article/chapterEnglish2007

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Chevy Chase, Md.Endocrine Society,2007
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LIBRIS-ID:oai:DiVA.org:oru-5218
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-5218URI
https://doi.org/10.1210/jc.2007-0960DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-13704URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:115826186URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Part of thesis: http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-5223
Objectives: Earlier research has suggested a positive association between Addison’s disease (AD) and celiac disease (CD).Wehave here investigated the risk of AD in individuals with CD from a general population cohort.Methods: Through the Swedish national registers we identified 14,366 individuals with a diagnosis of CD (1964–2003) and 70,095 reference individuals matched for age, sex, calendar year, and county of residence. We used Cox regression to estimate hazard ratios (HRs) for subsequent AD. Analyses were restricted to individuals with more than 1 yr of follow-up and without AD prior to study entry or within 1 yr after study entry. Conditional logistic regression estimated the odds ratio for CD in individuals with prior AD.Results: There was a statistically significantly positive association between CD and subsequent AD [HR _ 11.4; 95% confidence interval (CI) _ 4.4 –29.6]. This risk increase was seen in both children and adults and did not change with adjustment for diabetes mellitus or socioeconomic status. When we restricted reference individuals to inpatients, the adjusted HR for AD was 4.6 (95% CI _ 1.9 –11.4). Individuals with prior AD were at increased risk of CD (odds ratio _ 8.6; 95% CI _ 3.4 –21.8).Conclusions: This study found a highly increased risk of AD in individuals with CD. This relationship was independent of temporal sequence. We therefore recommend that individuals with AD should be screened for CD. We also suggest an increased awareness of AD in individuals with CD.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
adrenocortical insufficiency
autoimmune; celiac; cohort study; Addison disease
Paediatric medicine
Pediatrisk medicin
Gastroenterology
Gastroenterologi
Endocrinology
Endokrinologi
MEDICINE
MEDICIN
Pediatrik
Pediatrics
Epidemiologi
Epidemiology

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Montgomery, Scott M.Karolinska Institutet,Örebro universitet,Hälsoakademin(Swepub:oru)smy (author)
Kämpe, OlleUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)(Swepub:uu)ollekamp (author)
Ekbom, AndersKarolinska Institutet (author)
Ludvigsson, Jonas F.Karolinska Institutet (author)
Örebro universitetHälsoakademin (creator_code:org_t)

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In:Journal of Clinical Endocrinology and MetabolismChevy Chase, Md. : Endocrine Society92:9, s. 3595-35980021-972X1945-7197

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