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Risk of primary adr...
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Elfström, Peter,1974-Örebro universitet,Hälsoakademin
(author)
Risk of primary adrenal insufficiency in patients with celiac disease
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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Chevy Chase, Md.Endocrine Society,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-5218
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-5218URI
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https://doi.org/10.1210/jc.2007-0960DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-13704URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:115826186URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Part of thesis: http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-5223
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Objectives: Earlier research has suggested a positive association between Addison’s disease (AD) and celiac disease (CD).Wehave here investigated the risk of AD in individuals with CD from a general population cohort.Methods: Through the Swedish national registers we identified 14,366 individuals with a diagnosis of CD (1964–2003) and 70,095 reference individuals matched for age, sex, calendar year, and county of residence. We used Cox regression to estimate hazard ratios (HRs) for subsequent AD. Analyses were restricted to individuals with more than 1 yr of follow-up and without AD prior to study entry or within 1 yr after study entry. Conditional logistic regression estimated the odds ratio for CD in individuals with prior AD.Results: There was a statistically significantly positive association between CD and subsequent AD [HR _ 11.4; 95% confidence interval (CI) _ 4.4 –29.6]. This risk increase was seen in both children and adults and did not change with adjustment for diabetes mellitus or socioeconomic status. When we restricted reference individuals to inpatients, the adjusted HR for AD was 4.6 (95% CI _ 1.9 –11.4). Individuals with prior AD were at increased risk of CD (odds ratio _ 8.6; 95% CI _ 3.4 –21.8).Conclusions: This study found a highly increased risk of AD in individuals with CD. This relationship was independent of temporal sequence. We therefore recommend that individuals with AD should be screened for CD. We also suggest an increased awareness of AD in individuals with CD.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Montgomery, Scott M.Karolinska Institutet,Örebro universitet,Hälsoakademin(Swepub:oru)smy
(author)
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Kämpe, OlleUppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)(Swepub:uu)ollekamp
(author)
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Ekbom, AndersKarolinska Institutet
(author)
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Ludvigsson, Jonas F.Karolinska Institutet
(author)
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Örebro universitetHälsoakademin
(creator_code:org_t)
Related titles
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In:Journal of Clinical Endocrinology and MetabolismChevy Chase, Md. : Endocrine Society92:9, s. 3595-35980021-972X1945-7197
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