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Hematopoietic cance...
Hematopoietic cancer including lymphoma in celiac disease according to Marsh criteria 0-3
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- Elfström, Peter, 1974- (författare)
- Örebro universitet,Hälsoakademin
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Granath, Fredrik (författare)
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Ekström Smedby, Karin (författare)
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- Montgomery, Scott M. (författare)
- Örebro universitet,Hälsoakademin
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Askling, Johan (författare)
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Ekbom, Anders (författare)
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- Ludvigsson, Jonas F. (författare)
- Örebro universitet,Hälsoakademin
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Background: Celiac disease (CD) is associated with an increased risk of lymphoma, but it is unknown if borderline mucosal damage and latent CD are risk factors for lymphoma.Methods: We examined the risk of hematopoietic cancer in a nationwide population–based cohort of 28,800 individuals with biopsy-verified CD (villous atrophy, Marsh 3), 12,663 individuals with small intestinal inflammation (Marsh 1+2), and 3,551 with latent CD (positive antiendomysial, tissue transglutaminase or antigliadin test but normal mucosa on biopsy). The study participants were identified through all pathology departments (n=28) in Sweden and were biopsied in 1969-2006 (median: 1998). Cox regression estimated the hazard ratio (HR) for hematopoietic malignancies.Results: While biopsy-verified CD and intestinal inflammation were both statistically significantly associated with lymphoma (CD: HR = 3.18; 95% CI = 2.63-3.83; inflammation: 1.66; 1.28-2.17), latent CD was not (1.04; 0.44-2.43). CD was associated with both non-Hodgkin’s (NHL) and Hodgkin’s lymphoma (HL) (4.81; 3.81-6.07 and 4.39; 2.59-7.45 respectively). Risk estimates for NHL and HL were lower in inflammation (1.65; 1.15-2.38 and 1.48; 0.60-3.62 respectively) and latent CD (1.79; 0.74-4.34 and 1.08; 0.13-9.00 respectively). No increased risk of lymphoma was seen in children with a small intestinal biopsy. This study found no association between leukemia and small intestinal pathology.Conclusion: CD is associated with an increased risk of lymphoma. This risk increase was also seen in individuals with small intestinal inflammation. Latent CD is not associated with lymphoma of any kind, and positive CD serology alone cannot be used to predict future risk of lymphoma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- autoimmune
- biopsy
- celiac
- coeliac
- child
- cohort study
- cancer
- hematopoietic
- leukemia
- lymphoma
- pathology
- Paediatric medicine
- Pediatrisk medicin
- Gastroenterology
- Gastroenterologi
- MEDICINE
- MEDICIN
- Pediatrik
- Pediatrics
- Epidemiology
- Epidemiologi
- Medicin
- Medicine
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)