Adipose tissue concentrations of persistent organic pollutants and the risk of prostate cancer

OBJECTIVE: We sought to study the concentrations of certain persistent organic pollutants with endocrine-disrupting properties in cases with prostate cancer and controls with benign prostate hyperplasia. METHODS: Adipose tissue was obtained from 58 cases and 20 controls. RESULTS: The median concentration among controls was used as cut-off in the statistical analysis. In the total material, a greater-than median concentration of PCB congener 153 yielded an odds ratio (OR) of 3.15 and 95% confidence interval (CI) of 1.04-9.54 and one chlordane type, trans-chlordane, yielded OR 3.49 (95% CI = 1.08-11.2). In the group of case subjects with PSA levels greater than the median level of 16.5 ng/mL, PCB 153 was OR 30.3 (95% CI = 3.24-284), hexachlorobenzene OR = 9.84 (95% CI = 1.99-48.5), trans-chlordane OR = 11.0 (95% CI = 1.87-64.9), and the chlordane-type MC6 OR = 7.58 (95% CI = 1.65-34.9). The grouping of PCBs according to structural and biological activity was found to produce significantly increased risks for enzyme and phenobarbital-inducing PCBs and lower chlorinated PCBs in the case group with PSA levels greater than 16.5 ng/mL. CONCLUSIONS: These chemicals might be of etiologic significance but need to be further investigated. The biological relevance of the arbitrary cut-off point of PSA is unclear.

NATURVETENSKAP Kemi hsv//swe
NATURAL SCIENCES Chemical Sciences hsv//eng
NATURVETENSKAP Geovetenskap och miljövetenskap Miljövetenskap hsv//swe
NATURAL SCIENCES Earth and Related Environmental Sciences Environmental Sciences hsv//eng
MEDICINE
MEDICIN
NATURAL SCIENCES
NATURVETENSKAP
Chemistry
Kemi
Environmental chemistry
Miljökemi
Chemistry
Kemi
Environmental Chemistry
Miljökemi

Andersson, Swen-Olof (författare)
Carlberg, Michael (författare)
Bohr, Louise (författare)
van Bavel, BertÖrebro universitet,Institutionen för naturvetenskap,MTM(Swepub:oru)bvl (författare)
Lindström, GunillaÖrebro universitet,Institutionen för naturvetenskap,MTM(Swepub:oru)glm (författare)
Björnfoth, HelenÖrebro universitet,Institutionen för naturvetenskap,MTM(Swepub:oru)hbh (författare)
Ginman, Claes (författare)
Örebro universitetInstitutionen för naturvetenskap (creator_code:org_t)

Ingår i:Journal of Occupational and Environmental Medicine: Ovid Technologies (Wolters Kluwer Health)48:7, s. 700-7071076-27521536-5948

Av författaren/redakt...: Hardell, Lennart; Andersson, Swen- ...; Carlberg, Michae ...; Bohr, Louise; van Bavel, Bert; Lindström, Gunil ...; visa fler...; Björnfoth, Helen; Ginman, Claes; visa färre...

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