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Development of an i...
Development of an index to define overall disease severity in IBD
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- Siegel, Corey A. (author)
- Dartmouth-Hitchcock Inflammatory Bowel Disease Center, Dartmouth-Hitchcock Medical Center, Lebanon NH, USA
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- Whitman, Cynthia B. (author)
- Department of Health Services, Cedars-Sinai Medical Center, Los Angeles CA, USA
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- Spiegel, Brennan M. R. (author)
- Department of Health Services, Cedars-Sinai Medical Center, Los Angeles CA, USA
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- Feagan, Brian (author)
- Department of Health Services, Cedars-Sinai Medical Center, Los Angeles California, USA
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- Sands, Bruce (author)
- Icahn School of Medicine at Mount Sinai, New York, USA
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- Loftus, Edward V., Jr (author)
- Mayo Clinic, Rochester MN, USA
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- Panaccione, Remo (author)
- University of Calgary, Calgary AB, Canada
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- D'Haens, Geert (author)
- Academic Medical Center, Amsterdam, Netherlands
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- Bernstein, Charles N. (author)
- University of Manitoba, Winnipeg MB, Canada
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- Gearry, Richard (author)
- University of Otago, Christchurch, New Zealand
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- Ng, Siew C. (author)
- Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China
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- Mantzaris, Gerassimos J. (author)
- Evangelismos-PolyCliniki-Ophthalmiatreion Hospital, Athens, Greece
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- Sartor, Balfour (author)
- University of North Carolina, Chapel Hill NC, USA
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- Silverberg, Mark S. (author)
- Mount Sinai Hospital, Toronto ON, Canada
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- Riddell, Robert (author)
- Mount Sinai Hospital, Toronto ON, Canada
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- Koutroubakis, Ioannis E. (author)
- University Hospital Heraklion, Crete, Greece
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- O'Morain, Colm (author)
- Faculty of Health Sciences Trinity College Dublin, Dublin, Ireland
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- Lakatos, Peter L. (author)
- Semmelweis University, Budapest, Hungary
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- McGovern, Dermot P. B. (author)
- Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai, Medical Center, Los Angeles CA, USA
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Reinisch, Walter (author)
- McMaster University, Hamilton ON, Canada
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- Rogler, Gerhard (author)
- University Hospital of Zuürich, Zurich, Switzerland
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- Kruis, Wolfgang (author)
- University of Cologne, Koln, Germany
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- Tysk, Curt, 1949- (author)
- Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Schreiber, Stefan (author)
- University Hopital Schleswig Holstein, Kiel, Germany
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- Danese, Silvio (author)
- Humanitas University, Milan, Italy
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- Sandborn, William (author)
- UCSD, San Diego CA, USA
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- Griffiths, Anne (author)
- Hospital for Sick Children, Toronto ON, Canada
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- Moum, Bjorn (author)
- Oslo University Hospital and University Oslo, Oslo, Norway
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- Gasche, Christoph (author)
- Medical University and General Hospital Vienna, Vienna, Austria
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- Pallone, Francesco (author)
- University of Rome Tor Vergata, Rome, Italy
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- Travis, Simon (author)
- Oxford University Hospital, Oxford, UK
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- Panes, Julian (author)
- Hospital Clinic de Barcelona, Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain
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- Colombel, Jean-Frederic (author)
- Icahn School of Medicine at Mount Sinai, New York, USA
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- Hanauer, Stephen (author)
- Northwestern Feinberg School of Medicine, Chicago IL, USA
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- Peyrin-Biroulet, Laurent (author)
- Inserm U954 and Centre Hospitaliers Régionaux et Universitaires (CHU) de Nancy, Lorraine University, Nancy, France
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(creator_code:org_t)
- 2016-10-25
- 2018
- English.
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In: Gut. - London, United Kingdom : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288. ; 67:2, s. 244-254
- Related links:
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https://ora.ox.ac.uk...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background and aim: Disease activity for Crohn's disease (CD) and UC is typically defined based on symptoms at a moment in time, and ignores the long-term burden of disease. The aims of this study were to select the attributes determining overall disease severity, to rank the importance of and to score these individual attributes for both CD and UC.Methods: Using a modified Delphi panel, 14 members of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) selected the most important attributes related to IBD. Eighteen IOIBD members then completed a statistical exercise (conjoint analysis) to create a relative ranking of these attributes. Adjusted utilities were developed by creating proportions for each level within an attribute.Results: For CD, 15.8% of overall disease severity was attributed to the presence of mucosal lesions, 10.9% to history of a fistula, 9.7% to history of abscess and 7.4% to history of intestinal resection. For UC, 18.1% of overall disease severity was attributed to mucosal lesions, followed by 14.0% for impact on daily activities, 11.2% C reactive protein and 10.1% for prior experience with biologics. Overall disease severity indices were created on a 100-point scale by applying each attribute's average importance to the adjusted utilities.Conclusions: Based on specialist opinion, overall CD severity was associated more with intestinal damage, in contrast to overall UC disease severity, which was more dependent on symptoms and impact on daily life. Once validated, disease severity indices may provide a useful tool for consistent assessment of overall disease severity in patients with IBD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Crohn's Disease
- IBD
- Ulcerative Colitis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Siegel, Corey A.
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Whitman, Cynthia ...
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Spiegel, Brennan ...
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Feagan, Brian
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Sands, Bruce
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Loftus, Edward V ...
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show more...
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Panaccione, Remo
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D'Haens, Geert
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Bernstein, Charl ...
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Gearry, Richard
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Ng, Siew C.
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Mantzaris, Geras ...
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Sartor, Balfour
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Silverberg, Mark ...
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Riddell, Robert
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Koutroubakis, Io ...
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O'Morain, Colm
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Lakatos, Peter L ...
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McGovern, Dermot ...
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Halfvarson, Jona ...
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Reinisch, Walter
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Rogler, Gerhard
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Kruis, Wolfgang
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Tysk, Curt, 1949 ...
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Schreiber, Stefa ...
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Danese, Silvio
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Sandborn, Willia ...
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Griffiths, Anne
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Moum, Bjorn
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Gasche, Christop ...
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Pallone, Frances ...
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Travis, Simon
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Panes, Julian
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Colombel, Jean-F ...
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Hanauer, Stephen
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Peyrin-Biroulet, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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Gut
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Örebro University