Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury

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Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury

Oresic, Matej, 1967- (författare): Turku Centre for Biotechnology, University of Turku, Turku, Finland; Turku Centre for Biotechnology, Åbo Akademi University, Turku, Finland; Steno Diabetes Center A/S, Gentofte, Denmark; VTT Technical Research Centre of Finland, Espoo, Finland

Posti, Jussi P. (författare): Division of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, Turku, Finland; Division of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland

Kamstrup-Nielsen, Maja H. (författare): Steno Diabetes Center A/S, Gentofte, Denmark

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Takala, Riikka S. K. (författare): Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, Turku, Finland

Lingsma, Hester F. (författare): Department of Public Health, Erasmus MC-University Medical Center, Rotterdam, Netherlands

Mattila, Ismo (författare): Steno Diabetes Center A/S, Gentofte, Denmark; VTT Technical Research Centre of Finland, Espoo, Finland

Jäntti, Sirkku (författare): VTT Technical Research Centre of Finland, VTT, Espoo, Finland

Katila, Ari J. (författare): Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, Turku, Finland

Carpenter, Keri L. H. (författare): Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

Ala-Seppälä, Henna (författare): Division of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland

Kyllönen, Anna (författare): Division of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland

Maanpää, Henna-Riikka (författare): Division of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland

Tallus, Jussi (författare): Division of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland

Coles, Jonathan P. (författare): Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

Heino, Iiro (författare): Division of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland

Frantzén, Janek (författare): Division of Clinical Neurosciences, Department of Neurosurgery, Turku University Hospital, Turku, Finland; Division of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland

Hutchinson, Peter J. (författare): Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

Menon, David K. (författare): Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

Tenovuo, Olli (författare): Division of Clinical Neurosciences, Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland; Department of Neurology, University of Turku, Turku, Finland

Hyötyläinen, Tuulia, 1971- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,Turku Centre for Biotechnology, University of Turku, Turku, Finland; Turku Centre for Biotechnology, Åbo Akademi University, Turku, Finland; Steno Diabetes Center A/S, Gentofte, Denmark; VTT Technical Research Centre of Finland, Espoo, Finland; Clinical Research Institute, Helsinki University Central Hospital, Helsinki, Finland; Department of Chemistry, Örebro University, Örebro, Sweden

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Elsevier, 2016
2016
Engelska.
Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 12, s. 118-126

Relaterad länk:: https://doi.org/10.1...; visa fler...; http://www.ebiomedic...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

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Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI is an example of a medical condition where there are still major lacks in diagnostics and outcome prediction. Here we apply comprehensive metabolic profiling of serum samples from TBI patients and controls in two independent cohorts. The discovery study included 144 TBI patients, with the samples taken at the time of hospitalization. The patients were diagnosed as severe (sTBI; n=22), moderate (moTBI; n=14) or mild TBI (mTBI; n=108) according to Glasgow Coma Scale. The control group (n=28) comprised of acute orthopedic non-brain injuries. The validation study included sTBI (n=23), moTBI (n=7), mTBI (n=37) patients and controls (n=27). We show that two medium-chain fatty acids (decanoic and octanoic acids) and sugar derivatives including 2,3-bisphosphoglyceric acid are strongly associated with severity of TBI, and most of them are also detected at high concentrations in brain microdialysates of TBI patients. Based on metabolite concentrations from TBI patients at the time of hospitalization, an algorithm was developed that accurately predicted the patient outcomes (AUC=0.84 in validation cohort). Addition of the metabolites to the established clinical model (CRASH), comprising clinical and computed tomography data, significantly improved prediction of patient outcomes. The identified 'TBI metabotype' in serum, that may be indicative of disrupted blood-brain barrier, of protective physiological response and altered metabolism due to head trauma, offers a new venue for the development of diagnostic and prognostic markers of broad spectrum of TBIs. (C) 2016 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Allmänmedicin

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Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury

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