Sökning: WFRF:(Fitzgerald Rebecca) >
Influence of GABA a...
Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model
-
- Marques, Tatiana M., 1980- (författare)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Moorepark, Teagasc Food Research Centre, Fermoy, Ireland; School of Microbiology, University College Cork, Cork, Ireland
-
- Patterson, E. (författare)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Moorepark, Teagasc Food Research Centre, Fermoy, Ireland; School of Microbiology, University College Cork, Cork, Ireland
-
- Wall, Rebecca, 1979- (författare)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland
-
visa fler...
-
- O'Sullivan, O. (författare)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre Moorepark, Fermoy, Ireland
-
- Fitzgerald, G. F. (författare)
- APC Microbiome Institute, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland
-
- Cotter, P. D. (författare)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre Moorepark, Fermoy, Ireland
-
- Dinan, T. G. (författare)
- APC Microbiome Institute, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland
-
- Cryan, J. F. (författare)
- APC Microbiome Institute, University College Cork, Cork, Ireland
-
- Ross, R. P. (författare)
- APC Microbiome Institute, University College Cork, Cork, Ireland
-
- Stanton, C. (författare)
- APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre Moorepark, Fermoy, Ireland
-
visa färre...
-
(creator_code:org_t)
- Wageningen, Netherlands : Wageningen Academic Publishers, 2016
- 2016
- Engelska.
-
Ingår i: Beneficial Microbes. - Wageningen, Netherlands : Wageningen Academic Publishers. - 1876-2883 .- 1876-2891. ; 7:3, s. 409-420
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- The aim of this study was to investigate if dietary administration of γ-aminobutyric acid (GABA)-producing Lactobacillus brevis DPC 6108 and pure GABA exert protective effects against the development of diabetes in streptozotocin (STZ)-induced diabetic Sprague Dawley rats. In a first experiment, healthy rats were divided in 3 groups (n=10/group) receiving placebo, 2.6 mg/kg body weight (bw) pure GABA or L. brevis DPC 6108 (~10(9)microorganisms). In a second experiment, rats (n=15/group) were randomised to five groups and four of these received an injection of STZ to induce type 1 diabetes. Diabetic and non-diabetic controls received placebo [4% (w/v) yeast extract in dH2O], while the other three diabetic groups received one of the following dietary supplements: 2.6 mg/kg bw GABA (low GABA), 200 mg/kg bw GABA (high GABA) or ~10(9) L. brevis DPC 6108. L. brevis DPC 6108 supplementation was associated with increased serum insulin levels (P<0.05), but did not alter other metabolic markers in healthy rats. Diabetes induced by STZ injection decreased body weight (P<0.05), increased intestinal length (P<0.05) and stimulated water and food intake. Insulin was decreased (P<0.05), whereas glucose was increased (P<0.001) in all diabetic groups, compared with non-diabetic controls. A decrease (P<0.01) in glucose levels was observed in diabetic rats receiving L. brevis DPC 6108, compared with diabetic-controls. Both the composition and diversity of the intestinal microbiota were affected by diabetes. Microbial diversity in diabetic rats supplemented with low GABA was not reduced (P>0.05), compared with non-diabetic controls while all other diabetic groups displayed reduced diversity (P<0.05). L. brevis DPC 6108 attenuated hyperglycaemia induced by diabetes but additional studies are needed to understand the mechanisms involved in this reduction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Streptozotocin
- type-1 diabetes
- probiotic
- γ-aminobutyric acid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Marques, Tatiana ...
-
Patterson, E.
-
Wall, Rebecca, 1 ...
-
O'Sullivan, O.
-
Fitzgerald, G. F ...
-
Cotter, P. D.
-
visa fler...
-
Dinan, T. G.
-
Cryan, J. F.
-
Ross, R. P.
-
Stanton, C.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Beneficial Micro ...
- Av lärosätet
-
Örebro universitet