Translational Epidemiologic Approaches to Understanding the Consequences of Early-Life Exposures

Funding Agencies:Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIM-SAM) NICHD NIMH
Prominent developmental theories posit a causal link between early-life exposures and later functioning. Yet, observed associations with early exposures may not reflect causal effects because of genetic and environmental confounding. The current manuscript describes how a systematic series of epidemiologic analyses that combine several genetically-informative designs and statistical approaches can help distinguish between competing theories. In particular, the manuscript details how combining the use of measured covariates with sibling-comparisons, cousin-comparisons, and additional designs can help elucidate the sources of covariation between early-life exposures and later outcomes, including the roles of (a) factors that are not shared in families, including a potential causal effect of the exposure; (b) carryover effects from the exposure of one child to the next; and (c) familial confounding. We also describe key assumptions and how they can be critically evaluated. Furthermore, we outline how subsequent analyses, including effect decomposition with respect to measured, plausible mediators, and quantitative genetic models can help further specify the underlying processes that account for the associations between early-life exposures and offspring outcomes.

Class, Quetzal A.Karolinska Institutet (författare)
Rickert, Martin E.Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA (författare)
Sujan, Ayesha C.Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA (författare)
Larsson, Henrik,1975-Karolinska Institutet(Swepub:oru)hiln (författare)
Kuja-Halkola, RalfKarolinska Institutet (författare)
Sjölander, ArvidKarolinska Institutet (författare)
Almqvist, CatarinaKarolinska Institutet, Stockholm, Sweden (författare)
Lichtenstein, PaulKarolinska Institutet (författare)
Oberg, A. SaraKarolinska Institutet, Stockholm, Sweden; Harvard T.H. Chan School of Public Health, Boston, USA (författare)
Karolinska InstitutetDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, USA (creator_code:org_t)

Ingår i:Behavior GeneticsNew York, USA : Springer46:3, s. 315-3280001-82441573-3297

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