Genetic and environmental influences on the relationship between ADHD symptoms and internalizing problems: A Chinese twin study

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Chen, Tian-JiaoInstitute of Child and Adolescent Health, School of Public Health, Health Science Center, Peking University, Beijing, China (författare)

Genetic and environmental influences on the relationship between ADHD symptoms and internalizing problems : A Chinese twin study

Artikel/kapitelEngelska2016

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2015-12-29
Hoboken, USA :John Wiley & Sons,2016
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LIBRIS-ID:oai:DiVA.org:oru-54483
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-54483URI
https://doi.org/10.1002/ajmg.b.32411DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:134856144URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

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Funding Agency:National Natural Science Foundation of China
Several twin studies have investigated the overlap between attention deficit hyperactivity disorder (ADHD) and externalizing problems; however, limited information is known regarding the genetic and environmental contribution to the overlap between ADHD and internalizing problems. This study examined the genetic and environmental influences on the variation in and covariation between ADHD symptoms and internalizing problems by using the Child Behavior Checklist (CBCL). We investigated 1,316 child and adolescent twins, including 780 monozygotic twins and 536 dizygotic twins, aged 6 years to 18 years from the Chinese Child and Adolescent Twin Registry. ADHD symptoms and internalizing problems were quantified through parent rating by using the Attention Problems Scale and other three scales, which include Anxious/Depressed, Withdrawn, and Somatic Complaints of CBCL. Genetic and environmental susceptibilities common to ADHD symptoms and internalizing problems were examined through bivariate twin modeling. Results showed that genetic factors substantially influenced the ADHD symptoms with a heritability of 72%. Modest genetic influences and substantial shared environmental influences (20-77%) were observed in the three internalizing problem scales. Common genetic and shared environmental influences were essential for the overlap between ADHD and the three internalizing problems respectively. Approximately one-fifth of the genetic variance of ADHD symptoms was shared with anxiety/depression. In conclusion, substantial genetic and shared environmental influences on ADHD symptoms and internalizing problems were observed in Chinese children and adolescents. Our finding supports a common etiology between ADHD and internalizing problems. This finding can also help explain the co-existence of these behavior problems. © 2015 Wiley Periodicals, Inc.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
NATURVETENSKAP Biologi Genetik hsv//swe
NATURAL SCIENCES Biological Sciences Genetics hsv//eng
ADHD
internalizing problems
genetics
twin study
CBCL

Biuppslag (personer, institutioner, konferenser, titlar ...)

Ji, Cheng-YeInstitute of Child and Adolescent Health, School of Public Health, Health Science Center, Peking University, Beijing, China (författare)
Wang, Shang-ShangInstitute of Child and Adolescent Health, School of Public Health, Health Science Center, Peking University, Beijing, China (författare)
Lichtenstein, PaulKarolinska Institutet (författare)
Larsson, Henrik,1975-Karolinska Institutet(Swepub:oru)hiln (författare)
Chang, ZhengKarolinska Institutet (författare)
Karolinska InstitutetInstitute of Child and Adolescent Health, School of Public Health, Health Science Center, Peking University, Beijing, China (creator_code:org_t)

Sammanhörande titlar

Ingår i:American Journal of Medical Genetics Part BHoboken, USA : John Wiley & Sons171:7, s. 931-9371552-48411552-485X

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American Journal of Medical Genetics Part B (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Chen, Tian-Jiao; Ji, Cheng-Ye; Wang, Shang-Shan ...; Lichtenstein, Pa ...; Larsson, Henrik, ...; Chang, Zheng

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Genetik

Artiklar i publikationen: American Journal ...

Av lärosätet: Örebro universitet; Karolinska Institutet

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