(WFRF:(Kuja Halkola Ralf)) srt2:(2015)
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- Brikell, IsabellKarolinska Institutet (author)
Heritability of attention-deficit hyperactivity disorder in adults
- Article/chapterEnglish2015
Publisher, publication year, extent ...
- 2015-06-30
- Hoboken, USA :Wiley-Blackwell,2015
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:oru-54505
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-54505URI
- https://doi.org/10.1002/ajmg.b.32335DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:131825042URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Symptoms often persist into adulthood, with a prevalence of 2.5-5% in adult populations. Twin studies in childhood consistently report high heritabilities of 70-80%, while studies in adult samples show only moderate heritability of 30-40% when estimated from self-ratings. This review summarizes the available research on the heritability of ADHD in adults. Three key findings are outlined: (i) self-ratings lead to relatively low heritability estimates of ADHD, independent of age and whether ratings refer to current or retrospective symptoms; (ii) studies relying on different informants to rate each twin within a pair (i.e., self-ratings and different parents/teachers rating each twin in a pair) consistently yield lower heritability estimates than studies relying on ratings from a single informant; (iii) studies using cross-informant data via either combined parent and self-ratings or clinical diagnoses information suggest that the heritability of ADHD in adults could be as high as 70-80%. Together, the reviewed studies suggest that the previously reported low heritability of ADHD in adults is unlikely to reflect a true developmental change. Instead, the drop in heritability is better explained by rater effects related to a switch from using one rater for both twins in a pair (parent/teacher) in childhood, to relying on self-ratings (where each twin rates themselves) of ADHD symptoms in adulthood. When rater effects are addressed using cross-informant approaches, the heritability of ADHD in adults appears to be comparable to the heritability of ADHD in childhood.
Subject headings and genre
- NATURVETENSKAP Biologi Genetik hsv//swe
- NATURAL SCIENCES Biological Sciences Genetics hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
- Adult ADHD
- twin studies
- rater effects
- genetics
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- Kuja-Halkola, RalfKarolinska Institutet (author)
- Larsson, Henrik,1975-Karolinska Institutet(Swepub:oru)hiln (author)
- Karolinska Institutet (creator_code:org_t)
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- In:American Journal of Medical Genetics Part BHoboken, USA : Wiley-Blackwell168:6, s. 406-4131552-48411552-485X
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