Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families

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Fraser, AbigailMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom (author)

Maternal diabetes in pregnancy and offspring cognitive ability : sibling study with 723,775 men from 579,857 families

Article/chapterEnglish2014

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2013-09-25
Springer,2014
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LIBRIS-ID:oai:DiVA.org:oru-54555
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-54555URI
https://doi.org/10.1007/s00125-013-3065-zDOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:127907822URI

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Language:English
Summary in:English

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Funding Agencies:UK Medical Research CouncilUK Medical Research Council fellowship G0701594Strategic Research Program in Epidemiology at Karolinska Institutet
AIMS/HYPOTHESIS: The aim of this study was to investigate the association between maternal diabetes in pregnancy and offspring cognitive ability and also to assess whether the association was due to intrauterine mechanisms or shared familial characteristics.METHODS: We linked national registers and conducted a prospective cohort study of singleton Swedish-born men to explore associations between maternal pregnancy diabetes and educational achievement at age 16 years, the age of completing compulsory education in Sweden (n = 391,545 men from 337,174 families, graduating in 1988-1997 and n = 326,033 men from 282,079 families, graduating in 1998-2009), and intelligence quotient (IQ) at the mandatory conscription examination at 18 years of age (n = 664,871 from 543,203 families).RESULTS: Among non-siblings, maternal diabetes in pregnancy was associated with lower offspring cognitive ability even after adjustment for maternal age at birth, parity, education, early-pregnancy BMI, offspring birth year, gestational age and birthweight. For example, in non-siblings, the IQ of men whose mothers had diabetes in their pregnancy was on average 1.36 points lower (95% CI -2.12, -0.60) than men whose mothers did not have diabetes. In comparison, we found no such association within sibships (mean difference 1.70; 95% CI -1.80, 5.21).CONCLUSIONS/INTERPRETATION: The association between maternal diabetes in pregnancy and offspring cognitive outcomes is likely explained by shared familial characteristics and not by an intrauterine mechanism.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Cognition; Diabetes; IQ; Pregnancy; Sibling comparison; Swedish registers

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Almqvist, CatarinaKarolinska Institutet (author)
Larsson, Henrik,1975-Karolinska Institutet(Swepub:oru)hiln (author)
Långström, NiklasKarolinska Institutet (author)
Lawlor, Debbie AMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom (author)
Karolinska InstitutetMRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom (creator_code:org_t)

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In:Diabetologia: Springer57:1, s. 102-1090012-186X1432-0428

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